儊儞僶乕

尋媶徯夘

尋媶撪梕徯夘

• 儗僩儘僩儔儞僗億僝儞桼棃偺堚揱巕Peg11/Rtl1偺戀斦偱偺栶妱
• 儗僩儘僩儔儞僗億僝儞桼棃偺堚揱巕Peg10偺婲尮偲僎僲儉僀儞僾儕儞僥傿儞僌偺惉棫
• 儗僩儘僩儔儞僗億僝儞桼棃偺堚揱巕Peg10偺屄懱敪惗偵偍偗傞昁恵側婡擻
• 懱嵶朎僋儘乕儞儅僂僗偺弶婜敪惗偵偍偗傞堎忢
• 懱嵶朎僋儘乕儞偺堚揱巕敪尰偼惓忢偐丠

榑暥堦棗

儕儞僋

• 暥晹壢妛徣壢妛尋媶旓曗彆嬥摿掕椞堟尋媶乽惗怋宯楍偺悽戙僒僀僋儖偲僄僺僎僲儉僱僢僩儚乕僋乿

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• 乽僸僩14斣愼怓懱偺僀儞僾儕儞僥傿儞僌惂屼僙儞僞乕偺堎忢偵傛偭偰堷偒婲偙偝傟傞廳撃側幘姵偲偦偺尨場堚揱巕偺摨掕乿乮搶嫗堛壢帟壢戝妛僾儗僗儕儕乕僗乯
• 僎僲儉婡擻夝愅偐傜尒偊偰偒偨歁擕椶恑壔乮JST press release乯
• 堚揱巕敪尰僐儞僩儘乕儖偱僋儘乕儞媄弍偺岦忋偵揥朷 乮壢妛媄弍怳嫽帠嬈抍曬 戞202崋乯
• 尋媶幒朘栤乮Nature Asia-Pacific乯
• 僎僲儉僀儞僾儕儞僥傿儞僌亅悽戙偵崗傒偙傑傟傞帪乮惗柦帍俁俉乯
• 僎僲儉僀儞僾儕儞僥傿儞僌偲儂擕椶偺恑壔乮惗柦帍俁俋乯
• Cause of sick clones contested (Nature "science update")
• Cells reprogram in 24 hours (Nature "science update")
• Genomic Imprinting Workshop 2006

懖嬈惗

STOP! 乽僸僩僋儘乕儞乿

嵟嬤偺尋媶惉壥

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儗僩儘僩儔儞僗億僝儞桼棃偺堚揱巕PEG10偺婲尮偲僎僲儉僀儞僾儕儞僥傿儞僌偺惉棫

儅僂僗偵偍偄偰戀斦宍惉偵昁恵偱偁傞PEG10堚揱巕偼丄LTR宆儗僩儘僩儔儞僗億僝儞偺堦庬偱偁傞Sushi-ichi偲憡摨惈傪桳偡傞丅偟偨偑偭偰丄PEG10偼儗僩儘僩儔儞僗億僝儞偲偟偰僎僲儉偵憓擖偝傟偨屻丄恑壔偺夁掱偱戀斦宍惉偵娭傢傞尰嵼偺婡擻傪妉摼偟偨偲峫偊傜傟傞丅捁椶傗唳拵椶偵偼PEG10偼懚嵼偟側偄偙偲偑傢偐偭偰偄傞丅歁擕椶摿堎揑側偙偺堚揱巕偑丄歁擕椶偺恑壔忋偳偺抜奒偵偍偄偰憓擖偝傟偨偺偐偼丄戀惗恑壔偲偺娭學傪扵傞忋偱廳梫偱偁傞丅

歁擕椶偵偼丄儅僂僗傗僸僩側偳偑娷傑傟傞恀廱椶丄僇儞僈儖乕傗僆億僢僒儉側偳偑娷傑傟傞桳戃椶丄僇儌僲僴僔丄僴儕儌僌儔偺懏偡傞扨岴椶偲偄偆俁偮偺僒僽僌儖乕僾偑偁傞丅嫽枴怺偄偙偲偵丄偙傟傜偺僒僽僌儖乕僾偼偦傟偧傟摿挜揑側惗怋條幃傪傕偮丅扨岴椶偼棏傪嶻傒擕偱巈傪堢偰傞棏惗歁擕椶偱偁傞丅桳戃椶偼恀廱椶偲摨偠偔戀惗歁擕椶偱偁傞偑丄戀斦偺婡擻偑掅偔敪惗抜奒偺斾妑揑憗偄帪婜偵巈傪暘曍偟丄堢帣擷偲屇偽傟傞戃偺拞偱巈傪堢偰傞丅恀廱椶偼婡擻偺崅偄敪払偟偨戀斦傪傕偪丄曣懱偺戀撪偱挿偔巈傪堢偰傞丅

巹偨偪偼丄偙傟傜偺僌儖乕僾偵偍偄偰PEG10偺桳柍傪挷傋傞偨傔丄僞儅乕儚儔價乕偲僇儌僲僴僔偵偮偄偰偦傟偧傟偺憡摨僎僲儉椞堟傪斾妑偟偨丅偦偺寢壥丄僞儅乕儚儔價乕偵偼崅搙偵曐懚偝傟偨PEG10偑懚嵼偡傞偑丄僇儌僲僴僔偵偼尒偮偐傜側偄偙偲偑柧傜偐偵側偭偨丅偙傟偼歁擕椶偑棏惗偐傜戀惗偵恑壔偟偰偄偔弶婜偺抜奒偵偍偄偰PEG10偑儗僩儘僩儔儞僗億僝儞偲偟偰僎僲儉偵憓擖偟丄歁擕椶偵偍偗傞戀斦宍惉偺婲尮偵枾愙偵娭學偟偨壜擻惈傪帵嵈偟偰偄傞丅

儅僂僗傗僸僩偵偍偄偰偼丄PEG10廃曈偼斾妑揑戝婯柾側僀儞僾儕儞僥傿儞僌椞堟偲側偭偰偄傞丅儗僩儘僩儔儞僗億僝儞桼棃偺堚揱巕傪娷傓僀儞僾儕儞僥傿儞僌椞堟偲偟偰丄僎僲儉僀儞僾儕儞僥傿儞僌偲儗僩儘僩儔儞僗億僝儞側偳偺奜棃攝楍偺晄妶惈壔婡峔偲偺娭楢惈傪扵傞忋偱旕忢偵嫽枴怺偄尋媶懳徾偱偁傞丅桳戃椶偱偼偙傟傑偱偵丄IGF2, IGF2R, PEG1/MEST偺俁堚揱巕偵偮偄偰僀儞僾儕儞僥傿儞僌傪庴偗傞偙偲偑柧傜偐偵側偭偰偄傞丅儅僂僗傑偨偼僸僩偵偍偗傞偙傟傜偺堚揱巕偼丄晝恊桼棃丄曣恊桼棃偺傾儗儖偱DNA儊僠儖壔偺堎側傞僎僲儉椞堟丄DMR (differentially methylated region)偵傛偭偰敪尰惂屼偝傟偰偄傞偙偲偑傢偐偭偰偄傞丅偟偐偟側偑傜丄桳戃椶偵偍偗傞憡摨椞堟偼CpG傾僀儔儞僪偵側偭偰偍傜偢DMR偑尒偮偐傜側偄偙偲偐傜丄桳戃椶偱偼恀廱椶偲偼堎側偭偨僀儞僾儕儞僥傿儞僌偺惂屼婡峔偑恑壔偟偨壜擻惈偑帵嵈偝傟偰偄傞丅偟偨偑偭偰巹偨偪偼丄PEG10偺懚嵼偡傞偙偲偑柧傜偐偵側偭偨桳戃椶偵偍偗傞憡摨椞堟偺僀儞僾儕儞僥傿儞僌偺忬懺傪恀廱椶偲斾妑偡傞偨傔丄僞儅乕儚儔價乕偺PEG10傗廃曈堚揱巕偺敪尰僷僞乕儞傪夝愅偟偨丅

偦偺寢壥丄儅僂僗偵偍偄偰偼偡傋偰僀儞僾儕儞僥傿儞僌堚揱巕偱偁傞Peg10, Sgce, Ppp1r9a, Asb4偺偆偪丄桳戃椶偱偼PEG10偩偗偑僀儞僾儕儞僥傿儞僌傪庴偗偰偄傞偙偲偑柧傜偐偵側偭偨丅偝傜偵丄PEG10偺5乫椞堟偵偍偄偰丄曣恊桼棃偺傾儗儖偺傒偑儊僠儖壔偝傟偰偄傞桳戃椶偱弶傔偰偺DMR傪敪尒偟偨丅嬃偄偨偙偲偵丄恀廱椶偵偍偄偰偼椬愙偡傞SGCE堚揱巕偺僾儘儌乕僞乕傕DMR偵娷傑傟傞偑丄桳戃椶偱偼尩枾偵PEG10懁偺傒偑DNA儊僠儖壔偺懳徾偲側偭偰偄偨丅偙傟傜偺寢壥偼丄儗僩儘僩儔儞僗億僝儞桼棃偱偁傞PEG10偑偙偺僀儞僾儕儞僥傿儞僌椞堟偺婲尮偱偁傝丄DMR偵傛傞僀儞僾儕儞僥傿儞僌惂屼婡峔偺嫟捠婲尮偑丄恀廱椶偲桳戃椶偑暘婒偟偨1壄2500枩擭埲忋慜偱偁傞偙偲傪帵偡偩偗偱側偔丄恀廱椶偱偼堦斒揑偱偁傞DMR偵傛傞僀儞僾儕儞僥傿儞僌惂屼婡峔偼丄儗僩儘僩儔儞僗億僝儞傗奜棃攝楍偵懳偡傞DNA儊僠儖壔偵傛傞晄妶惈壔婡峔傪婲尮偲偟偰偄傞壜擻惈傪採帵偟偰偄傞丅

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Suzuki S, Ono R, Narita T, Pask AJ, Shaw G, Wang C, Kohda T, Alsop AE, Marshall Graves JA, Kohara Y, Ishino F, Renfree MB, Kaneko-Ishino T.
Retrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting.
PLoS Genet. 2007 Apr 13;3(4)