廋巑乛攷巑壽掱偺妛惗傪曞廤
摉尋媶幒偱偼戝妛堾惗傗尋媶惗傪曞廤偟偰偄傑偡丅尋媶撪梕偵偮偄偰偼暘栰偺
尋媶徯夘偺儁乕僕媦傃丄埲壓偺嵟怴偺僥乕儅傪嶲徠偟偰偔偩偝偄丅尋媶偺柺敀偝傪暘偐偪崌偊傞丄堄梸偁傞戝妛堾惗傪曞廤偟偰偄傑偡丅
尋媶僥乕儅偼埲壓偺偲偍傝偱偡丅
1. 儗僩儘僩儔儞僗億僝儞桼棃偺歁擕椶摿堎揑妉摼堚揱巕孮偺夝愅
僸僩傪娷傓歁擕椶偼恑壔偺夁掱偱儗僩儘僩儔儞僗億僝儞偐傜怴偟偄堚揱巕傪婔偮傕妉摼偟偰偄傑偡丅摉尋媶幒偱偼丄僎僲儉僀儞僾儕儞僥傿儞僌尋媶偐傜敪尒偟偨Peg10/Sirh1丄Peg11/Sirh2偑儗僩儘僩儔儞僗億僝儞桼棃偺堚揱巕偱偁傝側偑傜戀斦宍惉偵昁恵側婡擻傪壥偨偟偰偄傞偙偲傪徹柧偟偰偒傑偟偨(Nat Genet 2006, 2008a, b)丅傑偨丄偙傟傜偼廳梫側僸僩偵偍偗傞幘姵堚揱巕偱偡丅傑偨丄Sirh7/Ldoc1偑戀斦偺嵶朎暘壔偵偐偐傢傝戀斦儂儖儌儞挷愡傪夘偟偰弌嶻偵塭嬁傪偁偨偊傞偙偲乮Development 2014)丄Sirh11/Zcchc16偑擼撪偺僲儖傾僪儗僫儕儞検偺挷愡偵傛傝丄拲堄椡傗徴摦惈側偳擣抦偵娭學偡傞擼婡擻偵娭學偡傞偙偲乮PLoS Genet 2015)傪曬崘偟偰偒傑偟偨丅偙偺傛偆偵丄偙傟傜偺妉摼堚揱巕偑歁擕椶偺戀惗偲擼婡擻偺恑壔偵廳梫側栶妱傪偼偨偟偰偒偨偙偲偑傢偐偭偰偒傑偟偨丅懠偵傕偄偔偮偐擼婡擻偵娭傢傞傕偺偑尒偮偐偭偰偄傑偡乮敪昞弨旛拞乯丅偙傟傜偺僲僢僋傾僂僩儅僂僗傪梡偄偨婡擻夝柧乮曄堎儅僂僗偺昞尰宆傪尒偮偗傞強偐傜丄偦偺暘巕婡峔偺夝柧傑偱乯傪扴摉偟偨偄恖傪媮傔傑偡丅
2. 弶婜泱偱偺堚揱巕敪尰夝愅
庴惛捈屻偺嵟弶偺堚揱巕敪尰乮zygotic gene activation)偵懳偡傞庬乆偺泱憖嶌乮懱嵶朎僋儘乕儞傗尠旝庼惛乯偑媦傏偡塭嬁傪夝愅偟偰偄傑偡丅儌僨儖摦暔偲偟偰偺儅僂僗傪梡偄偨尋媶偩偗偱側偔丄恖偺惗怋曗彆堛椕偵偍偄偰丄泱憖嶌媄弍偺埨慡惈偺岦忋傪栚巜偟偨媄弍夵椙傪栚巜偟偰偄傑偡丅偝傜偵丄僄僺僕僃僱僥傿僢僋側惂屼偵廳梫側扙儊僠儖壔偺夁掱偱偺巁壔揑僔僩僔儞廋忺墫婎偱偁傞僸僪儘僉僔儊僠儖僔僩僔儞偺侾墫婎扨埵偱偺夝愅朄傪壜擻偵偡傞怴偟偄媄弍偺奐敪傗丄嬌旝検僒儞僾儖傪梡偄偨micro-ChIP媄弍偺奐敪側偳丄撈帺偺傾僀僨傿傾偱怴偟偄媄弍傪奐敪偟偮偮丄歁擕椶偺弶婜泱偱偺堚揱巕敪尰惂屼丒僄僺僕僃僱僥傿僢僋惂屼偺夝柧傪峴偄傑偡丅師悽戙僔乕僋僄儞僒乕傪梡偄偨夝愅傕娷傔丄暘巕惗暔妛偲僶僀僆僀儞僼僅儅僥傿僢僋僗偺憃曽偵嫽枴偺偁傞妛惗傪媮傔偰偄傑偡丅
3. 挿嵔旕僐乕僪RNA乮lncRNA乯偺歁擕椶敪惗偵偍偗傞婡擻偺夝柧
嬤擭丄歁擕椶偱偼僞儞僷僋幙傪僐乕僪偟側偄旕僐乕僪RNA(non-coding RNA, ncRNA)偑懡検偵揮幨偝傟偰偄傞偙偲偑暘偐偭偰偒傑偟偨丅偙傟傜偺拞偱傕丄miRNA傪戙昞偲偡傞彫偝側ncRNA偺夝愅偼恑傒偮偮偁傝傑偡偑丄200n.t埲忋偺挿偄ncRNA(long noncoding RNA, lncRNA)偼婡擻偑柧傜偐偵側偭偰偄傞傕偺偑婬偱偁傝丄偦偺栶妱傪柧傜偐偵偡傞偙偲偑媮傔傜傟偰偄傞忬嫷偱偡丅杮尋媶幒偱偼lncRNA偺僲僢僋傾僂僩儅僂僗傪夝愅偡傞偙偲偵傛傝丄lncRNA偺敪惗偵偍偗傞婡擻傪柧傜偐偵偡傞偙偲傪峴偭偰偄傑偡丅偙偺僲僢僋傾僂僩儅僂僗傪幘姵儌僨儖偲偟偰僸僩偺幘姵偺尨場媶柧偵宷偘偨偄偲峫偊偰偄傑偡丅
X愼怓懱嵞妶惈壔偼丄姴嵶朎偺懡擻惈傪昡壙偱偒傞巜昗偲偟偰拲栚傪梺傃傞傛偆偵側傝傑偟偨偑丄偙傟傑偱偺偲偙傠娙曋側儌僯僞乕朄偼曬崘偝傟偰偄傑偣傫丅 杮尋媶偱偼X 愼怓懱偺嵞妶惈壔傪儔僀僽僀儊乕僕儞僌偲偟偰専弌偡傞曽朄傪妋棫偟丄偦傟傪棙梡偟乽儕僾儘僌儔儈儞僌乿偺幚懱偺棟夝傪栚巜偟傑偡丅尋媶偺惉壥偼僸僩ES 嵶朎偺岠棪揑側嶌惢偵婑梌偡傞偲婜懸偱偒丄嵞惗堛椕偺敪揥偵戝偒側塭嬁傪梌偊傞壜擻惈偑偁傝傑偡丅
偦偺懠丄偍栤偄崌傢偣偼丄愇栰巎晀埗偵儊乕儖偵偰偛楢棈偔偩偝偄丅
愇栰尋媶幒