丂崅摍恀妀惗暔偱偼丄妀偵僐乕僪偝傟傞堚揱巕偺懡偔偼僀儞僩儘儞偵傛偭偰暘抐壔偝傟偰偄傞丅偝傜偵僸僩偱偼丄RNA億儕儊儗乕僗II偵傛偭偰揮幨偝傟傞堦師揮幨嶻暔偺偆偪幚偵俋俆亾埲忋偑僀儞僩儘儞偱偁傞丅偙傟傜偺偙偲偼丄僀儞僩儘儞傪彍偔斀墳丄偡側傢偪mRNA僗僾儔僀僔儞僌偑堚揱巕敪尰偵偼昁恵偱偁傝丄彍嫀偝傟偨僀儞僩儘儞偑妀撪偱偒偪傫偲戙幱偝傟傞偙偲偑昁梫偱偁傞偙偲傪帵偟偰偄傞丅偙偺僀儞僩儘儞戙幱夁掱傪柧傜偐偵偟偨偄偲峫偊偰偄傞丅傑偨丄 mRNA僗僾儔僀僔儞僌偼扨偵僀儞僩儘儞傪彍嫀偡傞偩偗偺斀墳偱偼側偔丄僄僋僜儞偲僄僋僜儞偲偺楢寢晹嬤朤偵丄EJC偲偄偆摿堎揑側暋崌懱傪晅壛偟丄mRNA僗僾儔僀僔儞僌偲懠偺嵶朎撪堚揱巕敪尰夁掱偲偺楢実傪峴偆夁掱偱偁傞偙偲偑柧傜偐偵側偭偰偒偨丅拞偱傕恄宱嵶朎偵偍偗傞嵶朎撪mRNA嬊嵼傗丄揮幨偲嫟栶偟偨DNA廋暅(TCR)偲偺楢実傪帵嵈偡傞僨乕僞傪摼偰偍傝丄mRNA僗僾儔僀僔儞僌偲偙傟傜偺夁掱偺怴偨側楢実傪柧傜偐偵偟偰偄偒偨偄偲峫偊偰偄傞丅

丂悽奅拞偺巰場偺偆偪丄埆惈庮釃偵傛傞巰朣偼13%傪愯傔傞偨傔乮2006擭搙WHO乯丄埆惈庮釃偺夋婜揑側帯椕朄偺妋棫偼嵟桪愭偱峴傢傟傞傋偒尋媶偺傂偲偮偱偁傞丅埆惈庮釃偱偼條乆側慖戰揑僗僾儔僀僔儞僌堎忢偑婲偒丄偦偺堎忢偑埆惈庮釃偺憹怋傪懀恑偟偰偄傞偙偲偑傢偐偭偰偄傞丅偦偺偨傔丄堎忢側僗僾儔僀僔儞僌傪惓忢嵶朎偱婲偒偰偄傞僗僾儔僀僔儞僌偵嬤偯偗傞偙偲偑偱偒傟偽桳梡側峈偑傫嵻偵側傝摼傞偲峫偊傜傟傞丅変乆偼丄偑傫嵶朎偵偍偗傞RNA慖戰揑僗僾儔僀僔儞僌惂屼婡峔偺夝柧偲偦偺婡峔傪棙梡偟偨妚怴揑峈偑傫嵻傪奐敪偡傞偙偲傪栚昗偲偟偰偄傞丅尰嵼丄埆惈庮釃憹怋偵娭傢傞廳梫側堚揱巕偺慖戰揑僗僾儔僀僔儞僌惂屼婡峔傪攟梴嵶朎傗in vitro僗僾儔僀僔儞僌側偳傪梡偄偰夝愅偟偰偄傞丅偝傜偵丄寀岝僞儞僷僋幙傪梈崌偝偣偨僗僾儔僀僔儞僌儗億乕僞乕偵傛傝丄僗僾儔僀僔儞僌傾僀僜僼僅乕儉偺愗姺偊傪攟梴嵶朎儗儀儖偱僀儊乕僕儞僌偡傞偙偲偵惉岟偟偰偄傞丅偙偺儗億乕僞乕偲掅暘巕壔崌暔儔僀僽儔儕乕傪慻傒崌傢偣傞偙偲偵傛傝峈偑傫嵻偺僗僋儕乕僯儞僌傪峴偆梊掕偱偁傞丅

丂僸僩僎僲儉偺夝撉偵傛傝丄518庬椶偵忋傞僞儞僷僋幙儕儞巁壔峺慺偺懚嵼偑梊憐偝傟偰偄傞丅偙傟傜偺儕儞巁壔峺慺偼惗柦尰徾偺懡嵤側嬊柺偱廳梫側栶妱傪壥偨偟丄傑偨丄婔偮偐偺儕儞巁壔峺慺偵懳偡傞摿堎揑慾奞嵻偑丄婛偵椪彴偺応偱庡梫側帯椕栻偲偟偰巊梡偝傟偰偄傞丅偟偐偟丄埶慠偲偟偰懡偔偺儕儞巁壔峺慺偵偍偄偰偼丄偦偺惗棟揑丒昦揑側婡擻偼夝柧偝傟偰偄側偄丅傑偨丄婡擻偑敾柧偟偰偄傞暔偵偍偄偰傕丄椪彴揑偵桳梡側慾奞嵻傗妶惈懀恑嵻偑摼傜傟偰偄傞暔偼偛偔傢偢偐偵偡偓側偄丅
丂変乆偼愭偵 SR protein kinase (SRPK) family丄cdc2-like kinase (Clk) family 偺摿堎揑側慾奞嵻傪悽奅偵愭嬱偗偰奐敪偟丄偙傟傜偺壔崌暔偑惗柦尰徾傪夝柧偡傞忋偱桳梡側僣乕儖偵側傝偆傞帠傪帵偟偨丅摿偵慜幰偵偮偄偰偼丄SRPK慾奞嵻偑峈僂僀儖僗嵻偺桳朷側憂栻僔乕僘偱偁傞帠傪尒偄偩偟偰偄傞丅
丂偙偺惉岟傪婎偵丄慾奞栻奐敪偺懳徾偲偡傞儕儞巁壔峺慺傪奼戝偟偰丄偝傜側傞扵嶕傪恑傔偰偄傞丅SRPK family 偲 Clk family 偼偦傟偧傟嬤墢偺儕儞巁壔峺慺僼傽儈儕乕偱偁傞偑丄懠偵傕 dual-specificity丂tyrosine-(Y)-phosphorylation regulated kinase (DYRK) family丄Homeodomain interracting protein kinase (HIPK) family丄human pre-messenger RNA processing 4 protein kinase (PRP4) 偑嬤墢偵埵抲偟丄慡懱偲偟偰傛傝戝偒側儕儞巁壔峺慺僼傽儈儕乕傪宍惉偟偰偄傞丅偙傟傜偺儕儞巁壔峺慺偼丄拞悤恄宱宯偺敪惗偍傛傃婡擻堐帩丄傾億僩乕僔僗偺惂屼丄pre-mRNA 僗僾儔僀僔儞僌摍偵娭梌偟偰偄傞丅変乆偼偙傟傜偺暘巕傪憤徧偟偰PSYCHIK 僼傽儈儕乕 (PRP4丄SRPK丄DYRK丄Clk丄HIPK Family乯偲屇傇帠傪採彞偟丄偦傟偧傟偺僼傽儈儕乕偵懳偡傞摿堎揑慾奞嵻傪奐敪偟偰偄傞丅尰嵼丄婛偵摼傜傟偰偄傞怴婯壔崌暔偵懳偟偰丄儕儞巁壔峺慺偲慾奞嵻偺嫟寢徎峔憿夝愅傪峴偆偲摨帪偵丄偦偺尋媶僣乕儖偲偟偰偺桳梡惈媦傃丄憂栻僔乕僘偲偟偰偺壜擻惈偵偮偄偰専摙拞偱偁傞丅

丂揮幨場巕CREB偼cAMP偵墳摎偡傞擣幆攝楍乮CRE乯偵寢崌偡傞揮幨場巕偲偟偰摨掕偝傟丄摦暔奅偵峀偔曐懚偝傟偰偍傝丄儅僂僗偱偼CREB偑嬻娫擣幆丒婰壇側偳偺擼偺崅師婡擻偵廳梫側摥偒傪帩偮偙偲側偳偑帵偝傟偰偄傞丅堦曽丄惗壔妛揑丒嵶朎惗暔妛揑夝愅偐傜丄CREB妶惈壔偵帄傞嵶朎撪僔僌僫儖偲偟偰丄MAPK僇僗働乕僪丄CaM-K僇僗働乕僪丄cAMP-PKA宱楬側偳偑摨掕偝傟偰偄傞丅偟偐偟丄奺慻怐偵晛曊揑偵敪尰偡傞CREB偑丄偦傟偧傟偺嵶朎偱偳偺傛偆側巋寖偵墳摎偟偰偳偺宱楬偱妶惈壔偝傟丄偳偺堚揱巕偺敪尰惂屼傪捠偠偰惗暔屄懱慡懱偵塭嬁傪媦傏偡偐偺慡懱憸偼柧傜偐偵側偭偰偄側偄丅
丂変乆偼慄拵乮C. elegans乯偺CREB/crh-1偺堚揱巕傪扨棧偟丄堚揱巕攋夡姅傪嶌惢偟偰丄偙偺曄堎懱偑崅壏懴惈梒拵條梒拵桿摫峔惉惈偺昞尰宆傪帵偡偙偲傪尒弌偟偨丅懴惈梒拵偼崅壏丒婹夓丒崅僼僃儘儌儞偺娐嫬忦審偵傛傝桿摫偝傟傞摿庩側宍懺傪帩偭偨媥柊忬懺偺梒拵偱偁傞丅嬤擭丄懴惈梒拵宍惉偼慄拵偺XXX嵶朎偐傜撪暘斿偝傟傞偲峫偊傜傟傞僗僥儘僀僪丒儂儖儌儞偺嶌梡偵傛傝晧偵惂屼偝傟偰偄傞偙偲偑柧傜偐偲側偭偰偒偨丅変乆偼懱嵶朎偱晛曊揑偵敪尰偟偰偄傞CREB/crh-1偑懴惈梒拵宍惉惂屼偵偍偄偰婡擻偡傞慻怐傪摿掕偡傞偨傔偵偝傑偞傑側慻怐摿堎揑僾儘儌乕僞乕偱CREB/crh-1傪敪尰偟偰crh-1曄堎懱偺儗僗僉儏乕傪帋傒丄XXX嵶朎偱敪尰偝偣偨応崌偺傒懴惈梒拵條梒拵桿摫峔惉惈偺昞尰宆偑儗僗僉儏乕偝傟傞偙偲傪尒弌偟偨丅傑偨丄偙偺儗僗僉儏乕妶惈偵偼CREB偺妶惈壔帪偵儕儞巁壔偝傟傞Ser偑昁梫偱偁傞偙偲偑傢偐偭偨丅偙偺偙偲偼丄CREB/CRH-1偑慄拵偺撪暘斿嵶朎偱婡擻偟偰丄曄懱傪惂屼偡傞廳梫側忣曬揱払宱楬偺堦晹傪扴偭偰偄傞偙偲傪帵偟偰偄傞丅尰嵼丄XXX嵶朎偵偍偄偰CREB/CRH-1傪儕儞巁壔偟妶惈壔偡傞僾儘僥僀儞丒僉僫乕僛偺摨掕傪堚揱妛揑庤朄偱恑傔偰偄傞丅