戝妛堾擖帋忣曬 | 傾僋僙僗丒楢棈愭
尋媶奣梫
敪昞榑暥
尋媶幒儊儞僶乕
攱尨嫵庼僾儘僼傿乕儖
傾僋僙僗
儕儞僋
僀儀儞僩忣曬
尋媶擔帍
戝妛堾惗丒媄弍幰曞廤


尨挊榑暥
1. Nojima T, Oshiro-Ideue T, Nakanoya H, Kawamura H, Morimoto M, Kawaguchi Y, Kataoka N and Hagiwara M (2009) Herpesvirus protein ICP27 switches PML isoform by altering mRNA splicing. Nucleic Acids Res., 2009 Sep 3 [Epub ahead of print]
2. Jiang K, Patel NA, Watson JE, Apostolatos H, Kleiman E, Hanson O, Hagiwara, M., Cooper DR. (2009) Akt2 regulation of Cdc2-like kinases (Clk/Sty), serine/arginine-rich (SR) protein phosphorylation, and insulin-induced alternative splicing of PKCssII mRNA.丂Endocrinology, 150, 2087-2097.
3. Yomoda, J., Muraki, M., Kataoka, N., Hosoya, T., Suzuki, M., Hagiwara, M. and Kimura, H. (2008) Combination of Clk family kinase and SRp75丂modulates alternative splicing of Adenovirus E1A. Genes Cells, 13, 233-244.
4. Ohno, G., Hagiwara, M. and Kuroyanagi, H. (2008) STAR family RNA-binding protein ASD-2 regulates developmental switching of mutually exclusive alternative splicing in vivo. Genes and Dev., 22,360-374.
5. Kuroyanagi, H, Ohno, G., Mitani, S., and Hagiwara, M. (2007) Fox-1 family and SUP-12 coordinately regulate tissue-specific alternative splicing in vivo. Mol. Cell. Biol. 27, 8612-8621.
6. Ideue T, Sasaki Y, Hagiwara M and Hirose T. (2007) Introns play an essential role in splicing-dependent formation of the exon junction complex. Genes & Dev., 21, 1993-1998.
7. Kaida D, Motoyoshi H, Tashiro E, Nojima T, Hagiwara M, Ishigami K, Watanabe H, Kitahara T, Yoshida T, Nakajima H, Tani T, Horinouchi S and Yoshida M (2007) A novel cell cycle inhibitor spliceostatin A targets SF3b and inhibits both splicing and nuclear retention of pre-mRNA. Nature Chem. Biol., 3, 576-583.
8. Nojima,T., Hirose,T.,Kimura,H.,& Hagiwara,M. (2007) The interaction between cap-binding complex and REF is required for intronless mRNA export. J. Biol. Chem. 282,15645-15651.
9. Aida, T., Konishi,A., Hagiwara,M., 仌 Hashimoto,K. (2007) Shortened Life-Spans of Biotech Pioneer Patents in Japan: A Lesson from the DNA Chip. Nature Biotech. 25, 533-535.
10. Kimura, H., Takizawa N., Allemand, E., Hori, T., Iborra, F.J., Nozaki, N., Muraki, M., Hagiwara, M.., Krainer, A.R., Fukagawa, T., and Okawa, K. (2006) A novel histone-exchange factor, protein phosphatase 2Cg, mediates the exchange and dephosphorylation of H2A/H2B. J. Cell Biol. 175,389-400
11. Kuroyanagi, H., Kobayashi, T., Mitani, S., and Hagiwara, M. (2006) A transgenic reporter reveals cell-type-specific expression profiles and regulation mechanisms of alternatively-spliced exons in vivo. Nature Methods 3, 909-915
12. Wada, K., Howard, J.T., McConnell, P., Whitney, O., Lints, T., Rivas, M.V. Horita, H., Patterson, M.A., White, S.A., Scharff, C., Haesler, S., Zhao, S., Sakaguchi, H., Hagiwara, M., Shiraki, T., Hirozane-Kishikawa, T., Skene, P., Hayashizaki, Y., Carninci, P., and Jarvis, E.D. (2006) A molecular neuroethological approach for identifying and characterizing a cascade of behaviorally regulated genes. Proc Natl Acad Sci USA. 103(41):15212-15217
13. Hirose T., Ideue, T., Nagai, M., Hagiwara, M., Shu, M., and Steitz, J.A. (2006) A spliceosomal intron-binding protein, IBP160, links position-dependent assembly of intorn-encoded box C/C snoRNP to pre-mRNA splicing. Mol. Cell. 23(5):673-684
14. Fukuhara T, Hosoya T, Shimizu S, Sumi K, Oshiro T, Yoshinaka Y, Suzuki M, Yamamoto N, Herzenberg LA, Herzenberg LA and Hagiwara M (2006) Utilization of host SR protein kinases and RNA-splicing machinery during viral replication. Proc Natl Acad Sci USA. 103(30):11329-11333
15. Ohki, N. and Hagiwara, M. (2005) Bio-Object, a stochastic simulator for post-transcriptional regulation. Bioinformatics 21, 2478-2487.
16. Wada, K.,Sakaguchi, H.,Jarvis, E.,and Hagiwara, M. (2004) Differential expression of glutamate receptors in avian neural pathways for learned vocalization. J. Comp. Neurol. 476,44-64.
17. Muraki, M., Ohkawara, B.,Hosoya, T., Onogi, H.,Koizumi, J.,Koizumi, T., Sumi, K., Yomoda, J., Murray, M. V., Kimura, K., Furuichi, K., Shibuya, H., Krainer, A. R., Suzuki, M. and Hagiwara, M. (2004) Manipulation of alternative splicing by a newly developed inhibitor of Clks. J. Biol. Chem. 279, 24246-24254.
18. Takano, M., Koyama, Y., Ito, H., Hoshino, S.,Onogi, H.,Hagiwara, M., Furukawa, K. and Horigome,T(2004) Regulation of binding of lamin B receptor to chromatin by SR protein kinase and cdc2 kinase in Xenopus egg extracts. J. Biol. Chem. 279,13265-13271.
19. Inoue, K., Zama, T., Kamimoto, T., Aoki, R., Ikeda, Y., Kimura, H. & Hagiwara, M. (2004) TNFa-induced ATF3 Expression Is Bidirectionally Regulated by the JNK and ERK Pathways in Vascular Endothelial Cells. Gene to Cells. 1,59-70
20. Umehara, H., Nishii, Y., Morishima, M., Kakehi, Y., Kioka,N., Amachi,T., Koizumi,J., Hagiwara, M. & Ueda,K (2003) Effect of cisplatin treatment on speckled distribution of a serine/arginine-rich nuclear proteinCROP/Luc7A Biochem. Biophys. Res. Comm. 301,324-329.
21. Suzuki,H.,Wu, JH,,Hossain, K.,Ohhata,T., Du, J., Akhand, AA., Hayakawa, A., Kimura,H., Hagiwara ,M., 仌Nakashima,I.(2003) Involvement of MKK6 in TCRa beta(int)CD69(lo):a target population for apoptotic cell death in thymocytes. FASEB J.17-1538-40
22. Katsu, R., Onogi, H., Wada, K., Kawaguchi, K. & Hagiwara, M. (2002) Novel SR-related protein Clasp specifically interacts with inactivated Clk4 and induces the exon EB inclusion of Clk. J. Biol. Chem. 277, 44220-44228.
23. Suzuki, T., Yamakuni , T., Hagiwara, M. , & Ichinose, H. (2002) Identification of ATF-2 as a Transcriptional Regulator for the Tyrosine Hydroxylase Gene. J. Biol. Chem. 277, 40768-40774.
24. Kimura,丂Y., Corcoran, E.E., Eto K., Gengyo-Ando, K., Muramatsu, M., Kobayashi, R., Freedman, J.H., Mitani, S., Hagiwara, M., Means, A.R., & Tokumitsu H. (2002) A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. EMBO Rep. 3, 962-966.
25. Wada, K.,Inoue,K,& Hagiwara, M. (2002) Identification of methylated protein arginine N-methyltransferase 1,PRMT1 with a new expression cloning strategy. Biochem. Biophys. Acta. 1591,1-10.
26. Zama, Z., Aoki, R., Kamimoto, T., Inoue,K., Ikeda, Y. & Hagiwara M. (2002) A novel dual-specificity phosphatase SKRP1 interacts with the MAPKK MKK7 and inactivates the JNK MAPK pathway: Implication for the precise regulation of the particular MAPK pathway. J. Biol. Chem. 277, 23909-23918.
27. Zama, Z., Aoki, R., Kamimoto, T., Inoue,K., Ikeda, Y. & Hagiwara M. (2002) Scaffold role of a MAP linase phosphatase, SKRP1 for the JNK signaling pathway. J. Biol. Chem. 277, 23919-23926.
28. Kamimoto, T., Zama, T., Aoki, R., Muro, Y. & Hagiwara, M. (2001) Identification of a novel kinesin-related protein, KRMP1, as a target for mitotic peptidyl-prolyl isomerase Pin1. J. Biol. Chem. 276, 37520-37528.
29. Kojima, T., Zama, T., Wada, K., Onogi, H. & Hagiwara, M. (2001) Cloning of Human PRP4 Reveals Interaction with Clk1. J. Biol. Chem. 276, 32247-32256.
30. Osada, M., Inaba, R., Shinohara, H., Hagiwara, M., Nakamura, M. & Ikawa, Y. (2001) Regulatory Domain of Protein Stability of Human P51/TAP63, a P53 Homologue. Biochem. & Biophys. Res. Comm. 283, 1135-1141.
31. Aratani, S., Fujii, R., Oishi, T., Fujita, H., Amano, T., Ohshima, T., Hagiwara, M., Fukamizu, A. & Nakajima, T. (2001) Dual roles of RNA helicase A on CREB-dependent transcription. Mol. Cell. Biol., 21, 4460-4469.
32. Ueda, H.R., Hagiwara, M. & Kitano, H. (2001) Robust oscillations within the interlocked feedback model of Drosophila circadian rhythm. J. Theoret. Biol. 210, 401-406.
33. Kuroyanagi, H., Kimura, T., Wada, K., Hisamoto, N., Matsumoto, K. & Hagiwara, M. (2000) SPK-1, a C. elegans SR proteins kinase homologue, is essential for embryogenesis and required for germ line development. Mech. Dev.. 99, 51-64.
34. Muro,Y., Kamimoto,T., Tomita,Y., and Hagiwara, M., (2000) Spectrum of autoantibodies against a dynamin-related protein,dymple. Arthritis Rheumatism 43, 7, 1516-1519.
35. Inoue, K., Mizuno, T., Wada, K. & Hagiwara, M. (2000) Novel RING finger proteins, Air1p and 2p interact with Hmtlp and inhibit the arginine methylation of Np13p. J. Biol. Chem. 275, 32793-32799.
36. Usukura, J., Nishizawa, Y., Shimomura, A., Kobayashi, K., Nagatsu, T. & Hagiwara, M. (2000) Direct imaging of phosphorylation dependent congormational change and DNA binding of CREB by electron microscopy. Genes to Cells 5, 515-522.
37. Nagai, Y., Miyazaki, M., Aoki, R., Zama, T., Inoue, S., Hirose, K., Iino, M. & Hagiwara, M, (2000) A fluorescent indicator for visualizing cAMP-induced phosphorylation in vivo. Nat. Biotechnol. 18, 313-316.
38. Kawahara, K., Watanabe, S., Ohshima, T., Soejima, Y., Oishi, T., Aratani, S., Nakata, M., Shibata, M., Inoue, K., Amano, T., Fujii, R., Yanai, K., Hagiwara, M., Fukamizu, A., Maruyama, I. & Nakajima, T. (1999) Hypernuclear acetylation in atherosclerotic lesions and activated vascular smooth muscle cells. Biochem. Biophys. Res. Comm. 266, 417-424.
39. Sakaguchi, H., Wada, K., Maekawa, M., Watsuji, T. & Hagiwara, M, (1999) Song-induced phosphorylation of cAMP response element binding protein in the songbird brain. J. Neuroscience 19, 3973-3981.
40. Koizumi, J., Okamoto, Y., Onogi, H., Mayeda, A., and Krainer, A. & Hagiwara, M, (1999) The subcellular localization of SF2/ASF is regulated by the direct interaction with SR protein kinases (SRPKs). J. Biol. Chem. 274, 11125-11131.
41. Okamoto, Y., Onogi, H., Honda, R., Yasuda, H., Wakabayashi, T., Nimura, Y. & Hagiwara, M. (1998) cdc2 kinase-mediated phosphorylation of splicing factor SF2/ASF. Biochem. Biophys. Res. Comm. 249, 872-878
42. Yoshida, K., Imaki, J., Okamoto, Y., Iwakabe, H., Fujisawa, H., Matsuda, A., Nakanishi, S., Matsuda, H. & Hagiwara, M. (1998) CREB-induced transcriptional activation depends on mGluR6 in rod bipolar cells. Mol. Brain Res. 57, 241-247.
43. Shimomura, A., Okamoto, Y., Hirata, Y., Kobayashi, M., Kawakami, K., Kiuchi, K., Wakabayashi, T. & Hagiwara, M. (1998) Dominant negative ATF1 blocks cyclic AMP-induced neurite outgrowth in PC12D Cells. J. Neurochem. 70, 1029-1034.
44. Muro, Y., Ogawa, Y., Kato, Y. & Hagiwara, M. (1998) Autoantibody to thioredoxin reductase in an ovarian cancer patient. Biochem. Biophys. Res. Commun. 242, 267-271.
45. Kuroyanagi, N., Onogi, H., Wakabayashi, T. & Hagiwara, M. (1998) Novel SR-protein-specific kinase, SRPK2, disassembles nuclear speckles. Biochem. Biophys. Res. Commun. 242, 357-364.
46. Kamimoto, T., Nagai, Y., Onogi, H., Muro, Y., Wakabayashi, T. & Hagiwara, M. (1998) Dymple, a novel dynamin-like high molecular weight GTPase lacking a proline-rich carboxyl-terminal domain in mammalian cells. J. Biol. Chem. 273,1044-1051
47. Muro, Y., Kano, T., Sugiura, K. & Hagiwara, M. (1997) Low frequency of autoantibodies against Ki-67 antigen in Japanese patients with systemic autoimmune. J. Autoimmunity 10, 499-503.
48. Nomoto, S., Watanabe, Y., Ninomiya-Tsuji, J., Yang, L.-X., Kiuchi, K., Hagiwara, M., Hidaka, H., Matsumoto, K. & Irie, K. (1997) Functional analyses of mammalian protein kinase kinase C Isozymes in budding yeast and mammalian fibroblasts. Genes to Cells 2, 601-614.
49. Nagai, Y., Kojima, T., Muro, Y., Hachiya, T., Nishizawa, Y., Wakabayashi, T. & Hagiwara, M. (1997) Identification of a novel nuclear speckle-type protein, SPOP. FEBS Lett. 418, 23-26
50. Masunaga, R., Nagasaka, A., Nakai, A., Kotak, M., Sawai, Y., Oda, N., Mokuno, T., Shimazaki, K., Hayakawa, N., Kato, R., Hiran, E., Hagiwara, M., & Hidaka, H. (1997) Alteration of platelet aggregation in patients with thyroid disorders. Metabolism 46, 1128-1131.
51. Watsuji, T., Okamoto, Y., Emi, N., Katsuoka, Y. & Hagiwara. M. (1997) Controlled gene expression with a reverse tetracycline regulated retroviral vector (RTRV) system. Biochem. Biophys. Res. Commun. 234, 769-773
52. Watanabe, Y., Takaetsu, G., Hagiwara, M., Irie, K. & Matsumoto, K. (1997) Characterization of a serum response factor-like protein in Saccharomyces cerevisiae, Rlm1, which has transcriptional activity regulated by the Mpk1 (Slt2) Mitogen-activated protein kinase pathway. Mol. Cell. Biol. 17, 2615-2623.
53. Sugiura, K., Muro, Y., Nagai, Y. & Hagiwara, M. (1997) Expression cloning and intracellular localization of a human ZF5 homologue. Biochem. Biophys. Acta. 1352, 23-26
54. Muro, Y., Kamimoto, T. & Hagiwara, M. (1997) Anti-Mitosin antibodies in a patient with chronic graft-versus-host disease after allogenic bone marrow transplantation. Bone Marrow Transplantation 19, 951-953.
55. Kobayashi, M., Shimomura, A., Hagiwara, M. & Kawakami, K. (1997) Phosphorylation of ATF-1 enhances its DNA binding and transcription of the Na, K-ATPase a1 subunit gene promoter. Nucleic Acids Res. 25, 877-882.
56. Okajima, T., Okuno, S., Fujisawa, H. & Hagiwara, M. (1996) Nuclear localization of Ca2+/Calmodulin-dependent protein kinase IV and calspermin. Bioimage 4, 117-128.
57. Moriguchi, T., Toyoshima, F., Gotoh, Y., Iwamatsu, A., Irie, K., Mori, E., Kuroyanagi, N., Hagiwara, M., Matsumoto, K. & Nishida, E. (1996). Purification and identification of a major activator for p38 from osmotically shocked cells: Activation of MAPKK6 by osmotic shock, tumor necrosis factor-a and H2O2. J. Biol. Chem. 271, 26981-26988.
58. Okada, H., Miyamura, K., Ito, T., Hagiwara, M., Wakabayashi, T., Mizuno, M., Colosi, P., Kurtzman, G. & Yoshida, J. (1996) Gene therapy against an experimental glioma using adeno-associated virus vectors. Gene Therapy 3, 957-964.
59. Shimomura, A., Ogawa, Y., Fujisawa, H. & Hagiwara, M. (1996) Calmodulin-dependent protein kinase II potentiates transcriptional activation through ATF1, but not CREB. J. Biol. Chem. 271, 17957-17960.
60. Moriguchi, T., Kuroyanagi, N., Yamaguchi, K., Gotoh, Y., Irie, K., Kano, T., Shirakabe, K., Muro, Y., Shibuya, H., Matsumoto, K., Nishida, E. & Hagiwara, M. (1996) A novel kinase cascade mediated by MAPKK6 and MKK3. J. Biol. Chem. 271, 13675-13679.
61. Yasunami, M., Suzuki, K., Maruyama, H., Kawakami, H., Nagai, Y., Hagiwara, M. & Ohkubo, H. (1996) Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to NeuroD/BHF1. Biochem. Biophys. Res. Commun. 220, 754-758.
62. Okada, H., Yoshida, J., Sokabe, M., Wakabayashi, T. & Hagiwara, M. (1996) Suppression of CD44 expression decreases migration and invasion of human glioma cells. Int. J. Cancer. 66, 255-260
63. Yoshida, K., Imaki, J., Fujisawa, H., Harada, T., Ohki, K., Matsuda, H. and Hagiwara, M. (1996) Differential distribution of CaM kinases and induction of c-fos expression by flashing and sustained light in rat retinal cells. Invest. Ophthalmol. Vis. Sci. 37, 174-179.
64. Harada, T., Imaki, J., Hagiwara, M., Ohki, K., Takamura, M., Ohashi, T., Matsuda, H. & Yoshida, K. (1995) Phosphorylation of CREB in rat retinal cells after focal retinal injury. Exp. Eye. Res. 61,769-772
65. Kano, T., Suzuki, Y., Shibuya, M., Kiuchi, K. & Hagiwara, M. (1995) Cocaine-induced CREB phosphorylation and c-fos expression were suppressed in parkinsonism model mice. NeuroReport 6, 2197-2200.
66. Ohki, K., Yoshida, K., Hagiwara, M., Harada, T., Takamura, M., Ohashi, T., Matsuda, H. & Imaki, J. (1995) Nitric oxide induces c-fos gene expression via cyclic AMP response element binding protein (CREB) phosphorylation in rat retinal pigment epithelium. Brain Res. 696, 140-144.
67. Yoshida, K., Imaki, J., Matsuda, H. & Hagiwara, M. (1995) Light-induced CREB phosphorylation and gene expression in rat retinal cells. J. Neurochem. 65,1499-1504.
68. Okada, H., Yoshida, J., Seo, H., Wakabayashi, T., Sugita K. & Hagiwara, M. (1994). Anti-(glioma surface antigen) monoclonal antibody G-22 recognizes overexpressed CD44 in glioma cells. Cancer Immunol. Immunother. 39, 313-317.
69. Alberts, A.S., Arias, J., Hagiwara, M., Montminy, R.M. & Feramisco, J.R. (1994) Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei. J. Biol. Chem. 269,7623-7630.
70. Chrivia, J.C., Kwok, R.P., Lamb, N., Hagiwara, M., Montminy, R.M. & Goodman, R.H. (1993) Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859.
71. Nakamura, S., Wakusawa, S., Tajima, K., Miyamoto, K.-I., Hagiwara, M. & Hidaka, H. (1993) Effects of isoquinoline sulphonamide compounds on multi-drug-resistant P388 cells. J. Pharmacol. 45, 268-273.
72. Shimohama, S., Narita, M., Matsushima, H., Kimura, J., Kameyama, M., Hagiwara, M., Hidaka, H. & Taniguchi, T. (1993). Assessment of protein kinase C isozymes by two-site enzyme immunoassay in human brains and changes in Alzheimer乫s disease. Neurology 43, 1407-1413.
73. Hagiwara, M., Brindle, P., Harootunian, A., Armstrong, R., Rivier, J., Vale, W., Tsien, R., & Montminy, R. M. (1993) Stimulus-transcription coupling through the cAMP responsive factor CREB is rate-limited by the nuclear entry of PK-A. Mol. Cell. Biol. 13, 4852-4859.
74. Kawamoto, F., Fujioka, H., Murakami, R., Syafruddin, Hagiwara, M., Ishikawa, T. & Hidaka, H. (1993) The roles of Ca2+/calmodulin-andcGMP-dependent pathways in gametogenesis of a rodent malaria parasite, Plasmodium berghei. Eur. J. Cell. Biol. 60, 101-107.
75. Matsushima, H., Shimohama, S., Yamaoka, Y., Kimura, J., Taniguchi, T., Hagiwara, M. & Hidaka, H. (1993) Alteration of human platelet protein kinase C with normal aging. Mech. Ageing Dev. 69,129-36.
76. Hagiwara, M., Alberts, A., Brindle, P., Meinkoth, J., Feramisco, J., Deng, T., Karin, M., Shenolikar, S. & Montminy, M. (1992) Transcriptional attenuation following cAMP induction requires PP-1-mediated dephosphorylation of CREB. Cell 70, 105-13.
77. Okazaki, K., Watanabe, M., Ando, Y., Hagiwara, M., Terasawa, M. & Hidaka, H. (1992) Full sequence of neurocalcin, a novel calcium-binding protein abundant in central nervous system. Biochem. Biophys. Res. Commun. 185,147-53.
78. Goto, S., Kobayashi, M., Murate, T., Hotta, T., Hagiwara, M., Hoshino, T., Hidaka, H. & Saito, H. (1992). Thrombin-induced shape change in human megakaryoblastic leukemic cells, MEG-01, is mediated by protein kinase C. Thromb. Res. 68, 87-95.
79. Usuda, N., Hagiwara, M., Kong, Y., Shimizu, T., Hidaka, H. & Nagata, T. (1992) Immunohistochemical locazilation of protein kinase C isozymes. Acta. Histochem. Cytochem. 25, 707-715.
80. Wakusawa, S., Nakamura, S., Tajima, K., Miyamoto, K.-I., Hagiwara, M. & Hidaka, H. (1992) Overcoming of vinblastine resistance by isoquinoline sulfonamide compounds in adriamycin-resistant leukemiacells. Mol. Pharmacol. 41, 1034-1038.
81. Kato, M., Hagiwara, M. & Hidaka, H. (1992) Identification of a 80 kDa calmodulin-binding protein as a new Ca2+/calmodulin-dependent kinase by renaturation blotting assay (RBA). Biochem. J. 281, 339-42.
82. Iwamoto, T., Hagiwara, M., Hidaka, H., Isomura, T., Kioussis, D. & Nakashima, I. (1992) Accelerated proliferation and interleukin-2 production of thymocytes by stimulation of soluble anti-CD3 monoclonal antibody in transgenic mice carrying a rabbit protein kinase C alpha. J. Biol. Chem. 267, 18644-18648.
83. Uchida, C., Hagiwara, M. & Hidaka, H. (1991) Ca(2+)-independent, phospholipid-activated protein kinase in 3Y1 cells. Arch. Biochem. Biophys. 288, 421-426.
84. Terasawa, M., Hagiwara, M., Hachiya, T., Kobayashi, R., Obata, S., Wakabayashi, T. & Hidaka, H. (1991) Identification and characterization of protein kinase C-related enzymes in frog retina. Arch. Biochem. Biophys. 287, 213-7.
85. Hagiwara, M., Wakusawa, S., Miyamoto, K., & Hidaka, H. (1991). Obviation of drug resistance and affinity purification of P-glycoprotein by isoquinoline sulfonamides. Cancer Lett. 60, 103-7.
86. Sumi, M., Kiuchi, K., Ishikawa, T., Ishii, A., Hagiwara, M., Nagatsu, T. & Hidaka, H. (1991). The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contentsin PC12h cells. Biochem. Biophys. Res. Commun. 181, 968-975.
87. Shimizu, T., Usuda, N., Sugenoya, A., Masuda, H., Hagiwara, M., Hidaka, H., Nagata, T. & Iida, F. (1991) Immunohistochemical evidence for the overexpression of protein kinase C in proliferative diseases of human thyroid. Cell. Mol. Biol. 37, 813-821.
88. Usuda, N., Kong, Y., Hagiwara, M., Uchida, C., Terasawa, M., Nagata, T. & Hidaka, H. (1991) Differential localization of proteikinase C isozymes in retinal neurons. J. Cell Biol. 112, 1241-1247.
89. Kato, M., Hagiwara, M., Nimura, Y., Shionoya, S. & Hidaka, H. (1991). Purification and characterization of calcium-calmodulin kinase II from human parathyroid glands. J Endocrinol. 131, 155-162.
90. Koyama, Y., Fukaya, Y., Ueda, H., Hachiya, T., Hagiwara, M., Hidaka, H. & Marunouchi, T. (1990). Expression of protein kinase C isozyme in human Langerhans' cells. Acta. Derm. Venereol. Stockh. 70, 502-505.
91. Koyama, Y., Hachiya, T., Hagiwara, M., Kobayashi, M., Ohashi, K., Hoshino, T., Hidaka, H. & Marunouchi, T. (1990). Expression of kinaseC isozyme in epidermal Langerhans cells of the mouse. J. Invest. Dermatol. 94, 677-680.
92. Onoda, K., Hagiwara, M., Hachiya, T., Usuda, N., Nagata, T. & Hidaka, H. (1990) Different expression of protein kinase C isozymes inpancreatic islet cells. Endocrinology 126, 1235-40.
93. Chijiwa, T., Mishima, A., Hagiwara, M., Sano, M., Hayashi, K., Inoue,T., Naito, K., Toshioka, T. & Hidaka, H. (1990) Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide, of PC12D pheochromocytoma cells. J. Biol. Chem. 265, 5267-5272.
94. Miyamoto, K., Wakusawa, S., Nakamura, S., Koshiura, R., Otsuka, K., Naito, K., Hagiwara, M. & Hidaka, H. (1990) Circumvention of multi-drug resistance in P388 murine leukemia cells by a novel inhibitor of cyclic AMP-dependent protein kinase, H-87. Cancer Lett. 51, 37-42.
95. Hachiya, T., Hagiwara, M. & Hidaka, H. (1990) Immunoaffinity purification of type I protein kinase C. Arch. Biochem. Biophys. 280, 358-361.
96. Sumi, M., Hagiwara, M. & Hidaka, H. (1990) d-Indobufen inhibits collagen-induced intracellular calcium mobilization and inositol phosphates formation in human platelets. Thromb. Res. 59,319-326.
97. Shimosawa, S., Hachiya, T., Hagiwara, M., Usuda, N., Sugita, K. & Hidaka, H. (1990) Type-specific expression of protein kinase C isozymes in CNS tumor cells. Neurosci. Lett. 108, 11-16.
98. Hagiwara, M., Uchida, C., Usuda, N., Nagata, T., & Hidaka, H. (1990) Zeta-related protein kinase C in nuclei of nerve cells. Biochem. Biophys. Res. Commun. 168, 161-168.
99. Hagiwara, M., Hachiya, T., Watanabe, M., Usuda, N., Iida, F., Tamai, K. & Hidaka, H. (1990) Assessment of protein kinase C isozymes by enzyme immunoassay and overexpression of type II in thyroid adenocarcinoma. Cancer Res. 50, 5515-5519.
100. Hagiwara, M., Sumi, M., Usuda, N., Nagata, T. & Hidaka, H. (1990) Discrepancy of protein kinase C translocation and platelet aggregation-immunocytobiochemical evidence. Arch. Biochem. Biophys. 280, 201-5
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弌婅摿嫋 :
1.

敪柧偺柤徧丗抈敀幙偺儕儞巁壔傪應掕偡傞偨傔偺儌僯僞乕抈敀幙
嘆敪柧幰:攱尨惓晀丄堜忋晀丄塱堜峃梇
嘇弌婅擔丗1999擭9寧2擔 (PCT/JP99/04769)
嘊弌婅恖丗崙棫戝妛朄恖搶嫗堛壢帟壢戝妛

嘋敪柧偺撪梕偺奣棯丗抈敀偺儕儞巁壔偵傛傞峔憿曄壔傪FRET偵傛偭偰壜帇壔偡傞偙偲偵惉岟偟丄惗偒偨嵶朎撪偺儕儞巁壔斀墳傪寁帪揑偵儌僯僞乕偟掕検壔偱偒傞儌僯僞乕抈敀幙ART傪奐敪偟偨丅
2.

敪柧偺柤徧丗堎忢僗僾儔僀僔儞僌娭楢幘姵偺帯椕栻岓曗暔幙
嘆敪柧幰丗攱尨惓晀, 楅栘惓徍
嘇弌婅擔丗2005擭1寧6擔乮US? 11/029/470乯
2005擭1寧7擔乮AU? 2005200040乯
嘊弌婅恖丗崙棫戝妛朄恖搶嫗堛壢帟壢戝妛

嘋敪柧偺撪梕偺奣棯丗:Clk慾奞偵傛傝堎忢僗僾儔僀僔儞僌傪惀惓偡傞壔崌暔偵娭偡傞摿嫋丅
3.

敪柧偺柤徧丗SR抈敀幙偺儕儞巁壔惂屼曽朄丄偍傛傃SR抈敀幙偺妶惈惂屼嵻傪桳岠惉暘偲偡傞峈僂僀儖僗嵻
嘆敪柧幰丗攱尨惓晀丄暉尨晲巙丄楅栘惓徍丄嵶扟岶廩
嘇婎慴弌婅擔丗2003擭12寧26擔乮摿婅2003-435085乯
PCT弌婅擔丗2004擭12寧24擔(PCT/JP2004/19393)
嘊弌婅恖丗攱尨丂惓晀
嘋敪柧偺撪梕偺奣棯丗怴婯SR僞儞僷僋幙儕儞巁壔峺慺慾奞嵻偺僂僀儖僗憹怋梷惂偵娭偡傞摿嫋丅
4.

敪柧偺柤徧丗惗懱撪偵偍偗傞慖戰揑僗僾儔僀僔儞僌儗億乕僞乕宯
嘆敪柧幰丗攱尨惓晀丄崟桍廏恖
嘇暷崙丂弌婅擔丗2006擭9寧26擔(US? .11/904, 094)
嘊弌婅恖丗崙棫戝妛朄恖搶嫗堛壢帟壢戝妛
嘋敪柧偺撪梕偺奣棯丗慄拵偱慖戰揑僗僾儔僀僔儞僌傪壜帇壔偟丄惂屼場巕傗惂屼壔崌暔傪摨掕偡傞曽朄偵娭偡傞摿嫋丅
5.

敪柧偺柤徧丗峈DNA僂僀儖僗嶌梡傪桳偡傞傾僯儕儞桿摫懱
嘆敪柧幰丗攱尨惓晀丄彫栰栘攷丄嵶扟丂岶廩丄丂嶳杮丂惤丄丂栰拞丂梞夘丄丂暯徏丂弐峴
嘇婎慴弌婅擔丗2007擭8寧3擔? (摿婅 2007-203356)
PCT弌婅擔丗2008擭8寧1擔? (PCT / JP2008 / 064267 )
嘊弌婅恖丗姅幃夛幮丂僉僲僼傽乕儅
嘋敪柧偺撪梕偺奣棯丗 DNA僂僀儖僗偵懳偟偰峈僂僀儖僗嶌梡傪桳偡傞傾僯儕儞桿摫懱偵娭偡傞摿嫋丅
6.

敪柧偺柤徧丗敪岝僞儞僷僋幙傪梡偄偨儕儞巁壔峺慺慾奞暔幙偺僗僋儕乕僯儞僌曽朄
嘆敪柧幰丗攱尨惓晀丄栰懞撧旤巕丄栘懞峀丄栰嶈捈恗
嘇婎慴弌婅擔丗2008擭3寧4擔? (摿婅 2008-053502)
擔杮丂杮弌婅擔 丗2009擭3寧3擔? (摿婅 2009-049763)
嘊弌婅恖丗姅幃夛幮僉僲僼傽乕儅
嘋敪柧偺撪梕偺奣棯丗敪岝僞儞僷僋幙僄僋僆儕儞傪梡偄偰丄non-RI偱崅姶搙偐偮娙曋偵儕儞巁壔峺慺慾奞暔幙傪僗僋儕乕僯儞僌偡傞媄弍偵娭偡傞摿嫋丅
7.

敪柧偺柤徧丗峈RNA僂僀儖僗嶌梡傪桳偡傞傾僯儕儞桿摫懱
嘆敪柧幰丗攱尨惓晀丄彫栰栘攷丄楅栘惓徍丄屆嶳丂峗巕丄嵶扟丂岶廩丄丂暯徏丂弐峴
嘇婎慴弌婅擔丗2008擭3寧25擔? (摿婅 2008-078728)
PCT弌婅擔丗2009擭2寧4擔丂 (JP2009 / 052253)
嘊弌婅恖丗姅幃夛幮丂僉僲僼傽乕儅
嘋敪柧偺撪梕偺奣棯丗 RNA僂僀儖僗偵懳偟偰峈僂僀儖僗嶌梡傪桳偡傞傾僯儕儞桿摫懱偵娭偡傞摿嫋丅
8.

敪柧偺柤徧丗DYRK傪慾奞偡傞儀儞僝僠傾僝乕儖桿摫懱傪娷桳偡傞堛栻慻惉暔
嘆敪柧幰丗攱尨丂惓晀丄丂郌扟丂峗巌丄丂戝惣丂塸棟巕丄丂彫愳丂桋丄丂丂丂丂丂
嵶扟丂岶廩丄丂暯徏丂弐峴丄丂媑揷丂幚戙
嘇婎慴弌婅擔丗2008擭7寧23擔? (摿婅 2008-190277)
娯崙弌婅擔丗2008擭12寧31擔 (KR 10-2008-0138074)
嘊弌婅恖丗姅幃夛幮丂僉僲僼傽乕儅
嘋敪柧偺撪梕偺奣棯丗 DYRK慾奞擻傪桳偡傞儀儞僝僠傾僝乕儖桿摫懱偵娭偡傞摿嫋丅
9.

敪柧偺柤徧丗DYRK傪慾奞偡傞價僠傾僝乕儖桿摫懱傪娷桳偡傞堛栻慻惉暔
嘆敪柧幰丗攱尨丂惓晀丄丂栰拞丂梞夘丄丂搚嫶丂孿巕丄丂媑揷丂幚戙丄丂
暯徏丂弐峴
嘇婎慴弌婅擔丗2009擭2寧20擔? (摿婅 2009-038327)
嘊弌婅恖丗姅幃夛幮丂僉僲僼傽乕儅

嘋敪柧偺撪梕偺奣棯丗 DYRK慾奞擻傪桳偡傞價僠傾僝乕儖桿摫懱偵娭偡傞摿嫋丅
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