In the Division of Pathogenetic Regulation, intractable diseases including cardiovascular diseases, immune-related diseases and neuromuscular diseases, especially those caused by genetic abnormalities are investigated for the pathogenesis and genetic modification of disease expressivity by using genome informatics as well as cell biological and molecular pathological methods including genetic engineering to develop animal models.

The research activities of this department aims at elucidating how the elements constituting biosystems interact each other to generate the function of cells and organs.