1. 儗僠僲僀僪偺堛栻昳
2. 怴婯妀撪庴梕懱偺扵嶕丂乣怴婯僼傽乕儅僐僼僅傾偺扵嶕乣
3. 堛帟岺楢実偵傛傞働儈僇儖僶僀僆儘僕乕尋媶
4. 怴婯寀岝暔幙偍傛傃寀岝僙儞僒乕偺奐敪偲墳梡
5. 朏崄懓傾儈僪偺棫懱摿惈偲婡擻惈暘巕憂惢

儗僠僲僀僪偺堛栻昳

丂儗僠僲僀僪偼價僞儈儞A偺揤慠媦傃崌惉桿摫懱偺憤徧偱丄嵶朎偺暘壔丒憹怋丆宍懺宍惉丄柶塽婡擻側偳偺婎杮揑側惗柦尰徾傪摿堎揑偵惂屼偟偰偄傑偡丅 巹偨偪偼丄儗僠僲僀僪偺摿堎揑婡擻偺夝柧偲堛栻傊偺墳梡傪栚揑偵怴婯儗僠僲僀僪偺憂惢傪峴偭偰偄傑偡丅儗僠僲僀僪偺忋婰嶌梡偼俀偮偺妀撪庴梕懱RARs乮retinoic acid receptors乯偍傛傃RXR乮retinoid X receptors乯傪夘偟偨堚揱巕揮幨惂屼偵婎偯偒傑偡丅 摉尋媶幒偱偼丄RAR丄RXR偦傟偧傟偺摿堎揑側傾僑僯僗僩丄傾儞僞僑僯僗僩偺憂惢偵惉岟偟偰偄傑偡乮恾侾乯丅 巹偨偪偑愝寁崌惉偟偨壔崌暔偺偆偪丄RAR兛偍傛傃兝僒僽僞僀僾慖戰揑傾僑僯僗僩偱偁傞Am80乮堦斒柤丗僞儈僶儘僥儞乯偼 擄帯惈偍傛傃嵞敪偺媫惈慜崪悜媴惈敀寣昦乮APL乯偺帯椕栻偲偟偰変偑崙偱擣壜偝傟丄椪彴偺応偱梡偄傜傟偰偄傑偡丅

恾1.丂摉尋媶幒偱奐敪偟偨RAR偍傛傃RXR偦傟偧傟偵慖戰揑側傾僑僯僗僩偍傛傃傾儞僞僑僯僗僩偺峔憿

Kagechika, H. Vitamins 2017, 91, 121.
Kagechika, H. ;Shudo, K J. Med. Chem. 2005, 48, 5875.

丂巹偨偪偑奐敪偟偨Am80傪偼偠傔偲偡傞崌惉儗僠僲僀僪偼丄RAR丄RXR偺婡擻夝愅偺偨傔偺暘巕僾儘乕僽偲偟偰悽奅揑偵梡偄傜傟偰偄傑偡丅 儗僠僲僀僪偼尦乆丄旂晢幘姵丄偑傫椞堟偱偺墳梡偑専摙偝傟偰偄傑偟偨偑丄嵟嬤偱偼怱寣娗宯幘姵丄帺屓柶塽幘姵丄恄宱曄惈幘姵側偳偵懳偡傞桳岠惈偑帵偝傟偰偄傑偡丅 巹偨偪偼丄偙傟傜偺幘姵帯椕栻傊偺墳梡帇栰偵擖傟偰丄儗僠僲僀僪偺憂栻尋媶傪懕偗偰偄傑偡乮恾俀乯丅

Loppi, S. et al Brain Behav. Immunol. 2018,73, 670.
Huang, J. K. et al. Nature Neurosci. 2011, 14, 45.
Brum, P.-J. et al. FASEB J. 2015, 29, 671.
Ma, F. et al Nat. Commun. 2014, 5, 5494.

恾2.丂Am80偺丄條乆側幘姵帯椕栻偲偟偰偺揔墳奼戝偵岦偗偨帋傒

丂峏偵丄Am80偼帺屓柶塽幘姵丄恄宱曄惈幘姵傑偨丄嵟嬤丄RAR傪夘偝偢丄嵶朎幙儗僠僲僀儞巁寢崌僞儞僷僋幙乮CRABP乯傪夘偟偨儗僠僲僀僪偺婡擻傪扴偆壔崌暔傪尒偄偩偟偰偍傝丄 偦偺堛栻墳梡惈偵偮偄偰傕専摙乮暷崙偲偺嫟摨尋媶乯傪峴偭偰偄傑偡丅

Persaud, S. D. et al. Sci. Rep. 2016, 6, 22396.
Persaud, S. D. et al. Cell. Signal. 2013, 25, 19.

怴婯妀撪庴梕懱偺扵嶕丂乣怴婯僼傽乕儅僐僼僅傾偺扵嶕乣

丂儗僠僲僀僪偺庴梕懱偺傛偆偵帀梟惈彫暘巕乮儕僈儞僪乯偵寢崌偟偰堚揱巕揮幨傪惂屼偡傞庴梕懱偼妀撪庴梕懱偲屇偽傟偰偄傑偡丅 屆偔偼丄奺庬僗僥儘僀僪儂儖儌儞偺庴梕懱偑抦傜傟偰偄傑偟偨偑丄價僞儈儞D傗峛忬態儂儖儌儞偺庴梕懱傕妀撪庴梕懱偵暘椶偝傟丄 恖偵偼嶐擔枹抦偺傕偺傪娷傔偰48庬椶偺妀撪庴梕懱偑懚嵼偡傞偲偝傟偰偄傑偡丅儕僈儞僪埶懚揑揮幨場巕偱偁傞妀撪庴梕懱偼丆娻丆崪慹闋徢丆 摐擜昦丆摦柆峝壔側偳條乆側幘姵偺敪徢偲帯椕偵娭傢偭偰偄傑偡丅巹偨偪偼丆妀撪庴梕懱尋媶偺偨傔偺暘巕僾儘乕僽傗堛栻傊偺墳梡傪栚揑偵丄 庬乆偺妀撪庴梕懱偺枹抦偺撪場惈儕僈儞僪偺扵嶕傗崌惉儕僈儞僪偺憂惢傪峴偭偰偄傑偡丅 丂壔崌暔偺暘巕愝寁偵偍偄偰偼丄婛懚偺妶惈壔崌暔偲偼峔憿傗暔惈偺戝偒偔堎側傞怴婯峔憿傪摫擖偡傞愴棯傪偲偭偰偄丅 偙傟傑偱偵丄儂僂慺僋儔僗僞乕偱偁傞僇儖儃儔儞偲偄偆儐僯乕僋側峔憿傪婎斦偲偟偨妶惈壔崌暔傪憂惢偟偰偒傑偟偨乮恾俁乯丅

Mori, S. et al. Chem. Pharm. Bull. 2017, 65, 1051.
Fujii, S. et al. J. Am. Chem. Soc. 2011, 133, 20933.

恾3.丂儂僂慺僋儔僗僞乕乮僇儖儃儔儞乯傪慳悈惈崪奿偲偟偰梡偄偨惗棟妶惈暔幙偺憂惢

丂嵟嬤偱偼丄働僀慺丄僎儖儅僯僂儉偲偄偭偨崅廃婜戞14懓尦慺傪娷傓姱擻婎傗儁儞僞僼儖僆儘僗儖僼傽僯儖乮SF5乯婎傗僥僩儔僼儖僆儘僗儖僼傽僯儖乮SF4乯婎偲偄偭偨丄 儐僯乕僋側晹暘峔憿傪堛栻暘巕傊墳梡偡傞専摙傪峴偭偰偄傑偡丅

堛帟岺楢実偵傛傞働儈僇儖僶僀僆儘僕乕尋媶

丂巹偨偪偼丄帺暘偨偪偑奐敪偟偨儗僠僲僀僪傗奺庬妀撪庴梕懱儕僈儞僪傪梡偄偰懡偔偺惗柦壢妛丄堛妛尋媶幰偲嫟摨尋媶傪峴偭偰偄傑偡丅 丂峏偵丄惗柦壢妛丄堛妛尋媶幰偺尋媶偵崌惉壔妛揑棫応偐傜嶲夋偟丄憂栻傪巙岦偟偨嫟摨尋媶傪揥奐偟偰偄傑偡丅

Qin, X.-Y. et al. Proc. Nat. Acad. Sci. USA 2018, 115, 4969.
himada, S. et al. Br J Cancer 2018, 118, 972.

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嘆 傾僋傾億儕儞2偺儕儞巁壔傪懀恑偡傞暘巕偺憂惢丂(杮妛堛妛晹恡憻撪壢妛暘栰偲偺嫟摨尋媶)丂 丂
丂傾僋傾億儕儞2乮AQP2乯偼恡憻廤崌娗偵懚嵼偡傞悈暘巕僠儍僱儖偱偡丅 AQP2偺婡擻晄慡偼悈暘偺嵞媧廂傪慾奞偟丄懡擜側偳偺徢忬傪堷偒婲偙偡恡惈擜曵徢偺尨場偲側傝傑偡丅 巹偨偪偼杮妛恡憻撪壢偲偺嫟摨尋媶偵傛傝丄AQP2偺妶惈壔偵昁梫偱偁傞AQP2儕儞巁壔傪懀恑偡傞暘巕偺憂惢傪栚巜偟偰偄傑偡丅

Ando, F. et al. Nat. Commun. 2018, 9, 1411.
Ishigami-Yuasa, M. et al. Bioorg. Med. Chem. 2017, 25, 3845.

嘇儕傾僲僕儞庴梕懱傪昗揑偲偟偨憂栻尋媶丂(弴揤摪戝妛堛妛晹偲偺嫟摨尋媶)
丂儕傾僲僕儞庴梕懱乮RyR乯偼嬝彫朎懱枌忋偵懚嵼偡傞僇儖僔僂儉僠儍僱儖偱偁傝丄 揹埵巋寖偵墳偠偰嬝彫朎懱撪偺Ca2+傪曻弌偡傞偙偲偱崪奿嬝傗怱嬝偺廂弅塣摦偵娭梌偟偰偄傑偡丅 RyR偺曄堎偼Ca2+曻弌偺堎忢槾恑傪堷偒婲偙偟丄庬乆嬝幘姵傗晄惍柆偺尨場偲側傞偙偲偑抦傜傟偰偄傑偡丅 巹偨偪偼弴揤摪戝妛堛妛晹栻棟妛島嵗偲偺嫟摨尋媶偵傛傝丄RyR偵傛傞Ca2+曻弌傪梷惂偡傞暘巕偺憂惢尋媶傪峴偭偰偄傑偡丅

Murayama, T. et. al. Nat. Commun. 2021, 12, 4293.
Murayama, T. et al. Mol. Pharmacol. 2018, 94, 722

怴婯寀岝暔幙偍傛傃寀岝僙儞僒乕偺奐敪偲墳梡

丂岝偼乽帪娫乿偲乽嬻娫乿傪尩枾偵惂屼偟偨徠幩偑壜擻偱偁傝丄暘愅偵梡偄偨嵺偵偼憖嶌偑娙曋偐偮應掕帪娫偑抁偔偰偡傓偲偄偆棙揰傪桳偟偰偄傑偡丅 偦偺偨傔丄惗棟婡擻偺儕傾儖僞僀儉偐偮徻嵶側夝愅傗丄幘姵偺恌抐丄帯椕偵斈梡偝傟偰偄傑偡丅 巹偨偪偼丄寀岝暔幙偺桿摫懱儔僀僽儔儕乕傗丄怉暔偐傜拪弌丄扨棧偟偨寀岝惈偺揤慠暔側偳傪婎偵丄 怴偨側寀岝暔幙丄寀岝僙儞僒乕偺奐敪傪峴偭偰偄傑偡丅 偙傟傑偱偵丄怴婯峔憿傪桳偡傞丄摿掕偺pH椞堟偱偺傒寀岝傪敪偡傞壔崌暔傗丄擲搙僙儞僒乕偲側傞壔崌暔傪尒偄偩偟偰偒傑偟偨乮恾係乯丅 傑偨摼傜傟偨寀岝暔幙偺婡擻傪丄岝偵傛偭偰嫟桳寢崌偑愗抐偝傟傞岝暘夝惈曐岇婎偲偄偆暿偺岝婡擻惈暘巕偵墳梡偟偰偄傑偡丅 偙偆偟偨暘巕傪偆傑偔棙梡偡傟偽丄幘姵帯椕栻傪昦曄晹埵偺傒偵嶌梡偝偣傞庤朄偺奐敪傊偲偮側偑傝傑偡丅

Kato, D.; Hirano, T. et. al. J. Org. Chem. 2021, 86, 2264-2270.
Yokoo, H. et al. Eur. J. Org. Chem., 2018, 679.
Shiraishi, T. et al. New. J. Chem., 2015, 39, 8389.

恾4丏寀岝暔幙儔僀僽儔儕乕傗揤慠暔傪傕偲偵偟偨怴婯寀岝暔幙丄寀岝僙儞僒乕偺奐敪

朏崄懓傾儈僪偺棫懱摿惈偲婡擻惈暘巕憂惢

丂巹偨偪偼丄儀儞僘傾僯儕僪摍偺朏崄懓擇媺傾儈僪偑僩儔儞僗宆偱懚嵼偟偰偄傞偺偵懳偟偰丄 傾儈僪寢崌偺拏慺尨巕忋偵儊僠儖婎側偳偺傾儖僉儖婎傪摫擖偡傞偲朏崄娐偑岦偐偄崌偭偨cis宆傪嶣傞帠傪尒偄偩偟傑偟偨丅 偙偺惈幙偼傾儈僪寢崌偩偗偱側偔丄僂儗傾丆僌傾僯僕儞側偳偺娭楢偡傞姱擻婎偵傕偁偰偼傑傞堦斒揑側惈幙偱偡乮恾俆乯丅

Okamoto, I. 桳婡崌惉壔妛嫤夛帍, 2009, 1240.
Tanatani, A. 桳婡崌惉壔妛嫤夛帍, 2000, 58, 556.

恾5丏朏崄懓傾儈僪椶偺N-儊僠儖壔偵敽偆棫懱揮姺

丂cis宆傾儈僪傗僂儗傾偺愜傟嬋偑偭偨峔憿傗丄僗僋傾儖傾儈僪偺儐僯乕僋側摿惈傪婎斦偲偟偰丄 傜偣傫峔憿傗朏崄娐懡憌峔憿摍偺儐僯乕僋側棫懱峔憿偲摦揑嫇摦傪桳偡傞朏崄懓暘巕偺峔抸傗暘巕僗僀僢僠摍偺婡擻惈暘巕偺愝寁偵墳梡偟偰偄傑偡乮恾俇乯丅

Urushibara, K. et al. J. Org. Chem. 2018, 83, 14338.
Tojo, Y. et al. J. Org. Chem. 2018, 83, 4606.

恾6丏儐僯乕僋側峔憿傪帩偮朏崄懓壔崌暔偺峔抸

儁乕僕偺愭摢偵栠傞