戞343夞擄尋僙儈僫乕
壓婰偵傛傝擄尋僙儈僫乕傪奐嵜抳偟傑偡偺偱丄懡悢屼棃挳壓偝偄丅
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| 擔丂帪丂 | 丗 | 暯惉侾俇擭侾俀寧俇擔乮寧乯14:00乣16:00 |
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| 応丂強丂 | 丗 | 擄帯幘姵尋媶強乮弜壨戜抧嬫乯俀奒僙儈僫乕幒 |
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| 墘丂幰丂 | 丗 | Dr. Yi Zhang |
| | Dep. of Biochemistry & Biophysics, University of North Carolina at Chapel Hill |
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| 墘丂戣丂 | 丗 | Histone Modifications in Polycomb Silencing, X-inactivation and Cancer
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Yi Zhang愭惗偼丄僸僗僩儞廋忺尋媶偺戞堦恖幰偱偁傝丄堚揱巕揮幨惂屼偵偍偗傞僸僗僩儞廋忺偵娭偡傞Reinberg嫵庼偲嫟挊偺憤愢乮GENES & DEV. 15, 2343-2360, 2001乯偼僸僗僩儞僐乕僪壖愢傪夝愢偟偨傕偺偲偟偰峀偔抦傜傟偰偄傞丅崱夞偼丄僸僗僩儞儊僠儖壔峺慺偺僲僢僋傾僂僩儅僂僗偺夝愅傪岎偊偰丄嵟怴偺惉壥傪屼徯夘捀偒傑偡丅
Epigenetic modifications play important roles in diverse biological processes. To understand how epigenetic modifications participate in these diverse processes, our effort has been focused on identification and characterization of these enzymes. Our studies have uncovered a number of novel enzymes that are involved in histone methylation and ubiquitination. I will present evidence that support a direct link between the enzymatic activity and their functions in Polycomb silencing, X-inactivation and the development of cancer. Our studies raise the intriguing possibility that these enzymes may serve as potential targets for cancer intervention.
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| 楢棈愭 | 丗 | 杮僙儈僫乕偼僎僲儉墳梡堛晹栧僄僺僕僃僱僥傿僋僗暘栰(愇栰嫵庼)偲宍幙敪尰暘栰乮攱尨嫵庼乯偺嫟嵜偱偡丅楢棈偼撪慄8072偺愇栰傑偱偍婅偄偟傑偡丅 |
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