侾乯Nifuji A., Kellerman O., Kuboki Y., Wozney J., and Noda M. Perturbation of BMP signaling in somitogenesis resulted in vertebral and rib malformation in the axial skeletal formation. Journal of Bone and Mineral Research 12: 332-342,1997.
俀乯Murakami S., Nifuji A. and Noda M. Expression of indian hedgehog in osteoblasts and its posttranscriptional regulation by transforming growth factor-b. Endocrinology 138: 1972-1978, 1997.
俁乯Matsue M., Kageyama R., Denhardt D. T. and Noda M. Helix-loop-helix type transcription factor, HES-1, is expressed in osteoblastic cells, suppressed by 1,25(OH)2 vitamin D3 and modulates 1,25(OH)2 vitamin D3 enhancement of osteopontin expression. Bone 20: 329-334, 1997.
係乯Liu Y., Wozney J., Nifuji A., Olson E. and Noda M. Scleraxis is expressed in C2C12 myoblasts and its level is down-regulated by bone morphogenetic protein-2 (BMP2). Journal of Cellular Biochemistry 67: 1-9, 1997.
俆乯Liu Y., Watanabe H., Yamada, Y., Olson E., Nifuji A., and Noda M. Overexpression of a single helix-loop-helix type transcription factor, scleraxis, enhances aggrecan gene expression in osteoblastic osteosarcoma ROS17/2.8 cells. Journal of Biological Chemistry 272(47): 29880-29885,1997.
俇乯Ezura Y. Tournay O. Nifuji A. and Noda M. Identification of a novel suppressive vitamin D response sequence in the 5' flanking region of murine Id1 gene. Journal of Biological Chemistry, 272(47): 29865-29872, 1997.
俈乯Tsuji K., Ito Y. and Noda M. Expression of the PEBP2aA/AML3/CBFA1 gene is regulated by BMP4/7 heterodimer and its overexpression suppresses type I collagen and osteocalcin gene expression in osteoblastic and nonosteoblastic mesenchymal cells. Bone 22(2): 87-92, 1998.
俉乯Yamashita T., Nifuji A., Furuya K., Nabeshima Y. and Noda M. Elongation of the epiphyseal trabecular bone associated with precocious aging in transgenic mice carrying an insertional mutaiton in Klotho gene locus. Journal of Endocrinology 159:1-8,1998.
俋乯Rittling S., Matsumoto H.N., McKee M. , Novik K., An X.R., Nanci A., Denhardt D. and Noda M. Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. Journal of Bone and Mineral Research 13: 1101-1111, 1998.
10乯Kawauchi T., Nifuji A., Mataga N., Olson E.N., Bonaventure J., Shinomiya K., Liu Y. and Noda M. Fibriblast growth factor down-regulates expression of a basic helix-loop-helix type transcription factor, scleraxis, in chondrocyte-like cells, TC6. Journal of Cellular Biochemistry 70: 468-477, 1998.
11) Kawaguchi N. and Noda M. Osteoblastic cells regulate mi gene expression in cultured bone marrow cells. International Journal of Hematology 67: 275-281, 1998.
12)Li J., Tsuji K., Komori T., Miyazono K., Nifuji A., Wrana J. L., Ito Y. and Noda M. Smad2 overexpression enhances Smad4 gene expression and suppresses CBFA1 gene expression in osteoblastic osteosarcoma ROS17/2.8 cells. Journal of Biological Chemistry 273: 31009-31015, 1998.
13) Furuya K., Nifuji A., Rosen V. and Noda M. Effects of GDF7/BMP12 on proliferation and alkaline phosphatase expression in rat osteoblastic osteosarcoma ROS 17/2.8 cells. Journal of Cellular Biochemistry 72: 177-180, 1999.
14) Tamura M. and Noda M. Identification of DERMO-1 as a member of helix -llop-helix type transcription factors expressed in osteoblastic cells. Journal of Cellular Biochemistry 72: 167-176, 1999.
15) Nifuji A., and Noda M. Coordinated expression of noggin and BMPs during early skeletogenesis and induction of noggin expression by BMP7. Journal of Cellular Biochemistry 73:437-444, 1999.
16) Takazawa Y, Nifuji A, Mataga N, Noda M. Articular Cartilage Cells Immortalized by A Temperature Sensitive Mutant of SV40 Large T Antigen Survive and Form Cartilage Tissue in Articular Cartilage Environment, Journal of Cellular Biochemistry 74:338-345 1999.
17) Yoshitake Y, Rittling S.R., Denhardt D.T., Noda M. Osteopontin-deficient mice are resistant to ovariectomy-Induced bone resorption. Proceedings of the National Academy of Science U.S.A. 96:8156-8160, 1999.
18) Nifuji A., and Noda M. Coordinated expression of noggin and BMPs during early skeletogenesis and induction of noggin expression by BMP7. Journal of Bone and Mineral Research 14: 2057-66, 1999.
19) Yamashita T., Yo-ichi N., and Noda M. High-resolution uCT (micro-computed tomography) analyses of the abnormal trabecular bone structures in klotho gene mutant mice. Journal of Endocrinology 164:239-245, 2000.
20) Yamashita T., Yoshitake H.,Tsuji K., Kawaguchi N., Nabeshima Y., and Noda M. Retardation in bone resorption after bone marrow ablation in klotho mutant mice. Endocrinology 141: 438-445, 2000.
21) Murakami S. and Noda M. . Indian Hedgehog during Fracture Healing in Adult Rat Femora. Calcified Tissue International 66:272-276, 2000.
22) Takazawa Y., Tsuji K., Nifuji A., Kurosawa H., Ito Y., Noda M. An Osteogenesis-Related Transcription Factor, Cbfa1, Is Constitutively Expressed in Chondrocytic Cell Line, TC6, and its Expression Is Upregulated by BMP2. Journal of Endocrinology 164:239-579-586, 2000.
23) Sekiya I., Tsuji K, Koopman P, Watanabe H, Yamada Y, Shinomiya K, Nifuji A, Noda M. SOX9 Enhances Aggrecan Gene Promoter/Enhancer Activity and Is Upregulated by Retinoic Acid in a Cartilage-Derived Cell Line, TC6. Journal Biological Chemistry 275: 10738-10744, 2000.
24) Tsuji K. and Noda M. Identification and Expression of a Novel 3'-Exon of Mouse Runx1/Pebp2兛B/Cbfa2/AML1 Gene. Biochemical and Biophysical Research Communications 274:171-176,2000.
25) Kawaguchi N. and Noda M. Mitf Is Expressed in Osteoclast Progenitors in Vitro. Experimental Cell Research 260:284-291, 2000.
26) Furuya K., Nakamoto T., Shen Z. J., Tsuji K., Nifuji A., Hirai H. and Noda M. Overexpression of Cas-interactiong zinc finger protein (CIZ) Suppresses proliferation and enhances expression of type I collagen gene in osteoblast-like MC3T3E1 cells. Experimental Cell Research 260:261:329-335, 2000.
27) Shiraki-Iida T, Iida A, Nabeshima Y, Anazawa H, Nishikawa S, Noda M, Kuro-o M, Nabeshima Y. Improvement of multiple pathophysiological phenotypes of klotho (kl/kl) mice by adenovirus-mediated expression of the klotho gene. Journal of Gene Medicine 2(4):233-42, 2000.
28)Yoshida Y., Tanaka S., Umemori H., Minowa O., Usui M., Ikematsu N., Hosoda E., Imamura T., Kuno J., Yamasha T., Miyazono K., Noda M., Noda T., and Yamamoto T. Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 103:1085-1097, 2000.
29) Sekiya I., Koopman P, Tsuji K, Martin, S., Hrley, V., Yamada Y, Shinomiya K, Nifuji A, Noda M. Transcriptional Suppression of Sox9 Expression in Chondrocytes by Retinoic Acid Journal of Cellular Biochemistry (in press), 2001.
30) Kawaguchi N., Ono T., Mochii M. and Noda M. Spontaneous mutation in Mitf gene causes osteopetrosis in silver homozygote quail. Developmental Dynamics 220: 133-140, 2001.
31) Yamashita T., Sekiya I., Kawaguchi N., Nabeshma Y. and Noda M. Klotho-deficient mice are resistant to bone loss induced by unloading due to sciatic neurectomy. Journalof Endocrinology 168(2):347-351, 2001.
32) Asou Y., Rittling S.R., Yoshitake H., Tsuji K., Shinomiya K., Nifuji A., Denhardt D.T., and Noda M. Osteopontin facilitates angiogenesis, accumulation of osteoclasts and resorption in ectopic bone. Endocrinology Endocrinology 142:1325-1332 , 2001
33) Nemoto H., Rittling S. R., Yoshitake H., Furuya K., Amagasa T., Tsuji K., Nifuji A., Denhardt D. T. and Noda M. Osteopontin deficiency reduces experimental tumor cell metastasis to bone and soft tissues. Journal of Bone and Mineral Research 16:652-659, 2001.
34)Hideyo Ihara, David T.Denhardt,Koichi Furuya,Teruhito Yamashita, Yukari Muguruma,Kunikazu Tsuji, Keith A.Hruska, Kanji Higashio, Shoji Enomoto,Akira Nifuji, Susan R.Rittling, and丂Masaki Noda. Parathyroid Hormone-Induced Bone Resorption does not Occur in the Absence of Osteopontin Journal of Biological Chemistry 276:13065-13071 , 2001.
35) Ishijima,M., Rittling,S.R., Yamashita,T. , Tsuji,K., Kurosawa,H., ,Nifuji,A., Denhardt, D.T., and Noda,M. Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin. Journal of Experimental Medicine 193(3):399-404, 2001.
36) YumotoK., Ishijima,M., Rittling,S.R., Tsuji,K., Tsuchiya, Y., Kon,S., Nifuji,A., Uede, T., Denhardt, D.T., and Noda,M., Osteopontin-Deficiency Protects Joints Against Destruction in Anti-Type II Collagen Antibody-Induced Arthritis in Mice. Proceedings of the National Academy of Sciences USA 99: 4556-4561,2002.
俀丏 Reviews
侾乯崪偺旕僐儔乕僎儞抈敀偵偮偄偰: 椪彴惍宍奜壢俁俀姫 p79-81, 1997
俀乯TGF-兝僗乕僷乕僼傽儈儕乕偲崪宍惉: CLINICAL CALCIUM俈姫 p59-61, 1997
俁乯崪夎嵶朎偵偍偗傞hedgehog偺敪尰偲TGF-兝偵傛傞惂屼: 惍宍奜壢係俉姫 p1421, 1997
係乯Hedgehog: 惍宍奜壢係俉姫 p892, 1997
俆乯Paraxis: 僲僢僋傾僂僩儅僂僗丒僨乕僞僽僢僋 p388-389, 1997
俇乯 壨撪晀峴丒巐媨尓堦丒嶳塝埳嵕媑丒崟嵎媊榊丒栰揷惌庽丗愐拰恱懷崪壔晹桼棃嵶朎偵偍偗傞TGF兝superfamily ligand 庴梕懱偍傛傃TSC-俀俀堚揱巕偺敪尰.
俈) 栰揷惌庽丗媫揥奐偟偨崪戙幱尋媶偲崪慹闋徢偺帯椕偺枹棃. Molecular Medicine 35乮4乯丗416-421,1998.
8) 栰揷惌庽丒嶳壓徠恗丒擇摗彶丒屆壆崅堦丒撶搰梲堦丗屄懱榁壔儌僨儖偲偟偰偺Klotho堚揱巕曄埵傪傕偮儅僂僗偺崪偺宍懺妛揑堎忢. Molecular Medicine 35乮4乯丗444-447,1998.
9) 捯朚榓丒娭栴堦榊丒栰揷惌庽丗崪嵶朎偺暘壔偵娭梌偡傞Runt宆揮幨場巕Cbfa1/Pebp2兛A側傜傃偵崪擃崪宍惉偵偍偗傞Sox9偺婡擻偲崪宍惉堎忢.丂丂幚尡堛妛16乮11乯丗25-32,1998.
10) 懞忋弐堦丒栰揷惌庽丗僀儞僨傿傾儞僿僢僕儂僢僋偲崪奿宍惉. Molecular Medicine 35乮4乯丗500-508,1998.
11) 栰揷惌庽丒擇摗彶丒捯朚榓丒屆壆崅堦丒娭栴堦榊丒杻惗媊懃丒愳岥撧撧巕丒嶳岥徠恗丗TRANSCRIPTION FACTORS AND OSTEOBLASTS. Frontiers in Bioscience 3 乮8乯丗817-820,1998.
12) 栰揷惌庽丗Reverse Genetics 偱扵傞崪偺戙幱丒宍惉偺暘巕惗暔妛丗幚尡堛妛16乮2乯丗100-101,1998.
13) 嶳壓徠恗丒崟旜惤丒撶搰梲堦丒栰揷惌庽丗憗婜榁壔乮Klotho曄堎乯儅僂僗偵偍偗傞崪偺宍懺宍惉堎忢. 幚尡堛妛16乮2乯丗131-135,1998.
14)丂 擇摗彶丒栰揷惌庽丗Indian hedgehog 偲noggin 偺崪奿宍惉傊偺娭梌. 幚尡堛妛16乮2乯丗114-119,1998.
15) 栰揷惌庽丒擇摗彶丒愳岥撧撧巕丒丒屆壆崅堦丒嶳岥徠恗丒捯朚榓丗崪婎幙抈敀偲崪慹闋徢丗尰戙堛椕丂30丂乮12乯丗55-59,1998.
1俇乯. 栰揷惌庽丒擇摗彶丒嶳壓徠恗丒愳岥撧撧巕丒捯朚榓丗崪偺嵶朎偺摿堎惈傪婯掕偡傞揮幨場巕孮丗CLINICAL CALCIUM 9 乮4乯丄1999.
17) .栰揷惌庽丗崪嵞惗偲崱屻偺揥朷丅 戞111夞擔杮堛妛夛僔儞億僕僂儉婰榐廤,1998.
18) 栰揷惌庽丒擇摗彶丒嶳壓徠恗丒愳岥撧撧巕丒捯朚榓丗崪偺嵶朎偺摿堎惈傪婯掕偡傞揮幨場巕孮丗CLINICAL CALCIUM 9 乮4乯丄1999.
19) 崪夎嵶朎偺暘壔惂屼偵偐偐傢傞暘巕孮 栰揷惌庽丂捯朚榓丂崅郪桽帯丂屆壆崅堦丂 娭栴堦榊丂媀晲孾岾丂僯摗彶 嵟怴堛妛丂54(12): 96-102,1999
3.丂Presentations
侾乯Ezura Y., Tournay O. and Noda M. A novel negative vitamin D response sequence in the promoter of Id1: An inhibitory transcription factor in osteoblastic differentiation. The 43rd Annual Meeting of the Orthopaedic Research Society. San Francisco, California. February 9-13, 1997. Orthopaedic Research Society 22, 326.
俀乯Murakami S., McMahon A. P. and Noda M. Indian hedgehog gene is expressed in osteoblasts and is regulated by TGFb. The 43rd Annual Meeting of the Orthopaedic Research Society. San Francisco, California. February 9-13, 1997. Orthopaedic Research Society 22, 327.
俁乯Kawa-uchi T., Olson E., Mataga N. and Noda M. A basic helix-loop-helix transcription factor, scleraxis, is expressed in chondrocytes and is suppressed by FGF. The 43rd Annual Meeting of the Orthopaedic Research Society. San Francisco, California. February 9-13, 1997. Orthopaedic Research Society 22, 342.
係乯Ezura Y. , Tournay O. and Noda M. Vitamin D suppression Id1 gene expression via A 57bp negative vitamin D response sequence which forms a novel nuclear protein-DNA complex. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
俆乯Tsuji K. , Ito Y. and Noda M. Overexpression of PEBP2aA/AML3/CBFA1 suppresses osteocalcin and type I collagen gene expression in osteoblastic cells. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
俇乯Li J. , Wrana J.L. , Ito Y. and Noda M. MADR2 Overexpression suppresses PEBP2aA/AML-3/CBFA1 gene expression and osteocalcin-promoter activity in osteoblast-like cells. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
俈乯Tamura M. and Noda M. Identification of DERMO-1 as a member of helix-loop-helix type transcription factors expressed in osteoblastic cells. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
俉乯Nifuji A., Kellermann O., Harland R. and Noda M. Noggin promotion of chondrogenic differentiation and enhancement of its expression by BMP4/7 in a pluripotent mesenchymal cell line, C1. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
俋乯Nifuji A., Harland R. and Noda M. Noggin modulates BMP actions during the development of somite. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
10乯Rittling S., Matsumoto H.N., McKee M. , Novik K., An X.R., Nanci A., Denhardt D. and Noda M. Skeletal structure is normal while in vitro osteoclastogenesis is enhanced in mice deficient for osteopontin. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
11乯Takazawa Y., Mataga M. and Noda M. A chondrogenic cell line, TC6, established from articular cartilage of transgenic mice harboring SV40 large T antigen gene, form cartilaginous tissue in the environment of articular cartilage but not in subcutaneous tissues.. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
12乯Sekiya I., Koopman P., Watanabe H., Ezura Y., Yamada Y. and Noda M. SOX9 enhances aggrecan gene expression via the promoter region containing a single HMG-box-sequence a chondrogenic cell line TC6. The 19th Annual Meeting of American Society for Bone and Mineral Research, Cincinnati, Ohio, U.S.A. September 10-14, 1997. The Journal of Bone and Mineral Research 12.
13乯Yamashita T., Kuroo M., Nabeshima Y. and Noda M. Severe hypercalcification and osteopenia associated with precocious aging in a transgenic mouse carrying insertional mutation in Klotho gene locus.The 37th American Society for Cell Biology Annual Meeting, Washington, D.C., U.S.A. December 13-17, 1997. Molecular Biology of the Cell 8.
14乯Yamashita T., Kuroo M., Nabeshima Y. and Noda M. Rescue of severe hypercalcification associated with precocious aging in mice carrying insertional mutation in novel gene, Klotho, locus.The 37th American Society for Cell Biology Annual Meeting, Washington, D.C., U.S.A. December 13-17, 1997. Molecular Biology of the Cell 8.
15乯Yamashita T., Kuroo M., Nabeshima Y. and Noda M. Severe hypercalcification and osteopenia associated with precocious aging in a transgenic mouse carrying insertional mutation in a novel klotho gene locus.The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
16乯Sekiya I., Koopman P., Watanabe H., Ezura Y., Yamada Y. and Noda M. SOX9 enhances aggrecan gene expression via its action on the promoter region containing a single HMG-box-sequence in a chondrogenic cell line, TC6. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
17乯Takazawa Y., Mataga N. and Noda M. Articular cartilage environment supports the survival and differentiation of a condrogenic TC6 cells established from articular cartilage of transgenic mice harboring SV40 large T antigen. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
18乯Aso Y., Nifuji A. and Noda M. Developmental regulation of a basic helix-loop-helix type transcription factor, scleraxis, gene expression in ligaments, tendons and insertions of muscles. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
17) Yamashita T., Kuroo M., Nabeshima Y. and Noda M. Severe hypercalcification and osteopenia associated with precocious aging in a transgenic mouse carrying insertional mutation in a novel klotho gene locus.The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
18) Sekiya I., Koopman P., Watanabe H., Ezura Y., Yamada Y. and Noda M. SOX9 enhances aggrecan gene expression via its action on the promoter region containing a single HMG-box-sequence in a chondrogenic cell line, TC6. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
19) Takazawa Y., Mataga N. and Noda M. Articular cartilage environment supports the survival and differentiation of a condrogenic TC6 cells established from articular cartilage of transgenic mice harboring SV40 large T antigen. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
20) Aso Y., Nifuji A. and Noda M. Developmental regulation of a basic helix-loop-helix type transcription factor, scleraxis, gene expression in ligaments, tendons and insertions of muscles. The 44th Annual Meeting of the Orthopaedic Research Society, New Orleans, Louisiana, U.S.A. March 16-19, 1998.
21乯Yoshitake H., Rittling S., Denhardt D.T. and Noda M. Osteopontin-deficient mice are resistant to ovariectomy-induced bone loss. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
22乯Yoshitake H., Rittling S., Tsuji K., Yamashta T., Wong B., Choi W., Denhardt D. and Noda M. Osteopontin-deficient mice reveal increase in osteoclast number, enhanced TRANCE/RANKL/ODF expression in bone but are resistant to bone resorption that follows bone formation after bone marrow ablation. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
23乯Noda M., Rittling S., Muguruma Y., Asou Y., Yoshitake H., Tsuji K., and Denhardt D. Osteopontin-deficient(OD-) cells exhibit enhanced actin fiber formation and spreading while OD-osteoclasts are less efficient in remobing hydroxyapatite coated on glass and in recruitment to ectopically implanted bone matrix. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
24乯Sekiya I., Tsuji K., Nifuji A., Wheatly S.W., Koopman P. and Noda M. Sox9, a chondrogenic transcriptin factor, is the target of retionic acid suppression of the phenotypic gene expression in chondrocytes. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
25乯Nifuji A., Harland R.M. and Noda M. Noggin inhibition of cartilage development during skeletogenesis via its counteraction against BMP7 that upregulates noggin. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
26乯Takazawa Y., Rittling S., Furuya K., Yoshake H., Yamasha T., Denhardt D. and Noda M. Interleukin-1 induced bone resorption does not occur in osteopontin-deficient mice. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
27)Yamashita T., Nabeshima Y. and Noda M. Lack of klotho gene product, a suppressor of a syndrome resembling aging and a novel regulator of bone metabolism, blocks bone resorption after bone marrow ablations. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
28乯Tsuji K., Kraut N., Groudine M. and Noda M. A somite related transcription modulator, I-mfa (inhibitor of MyoD family A), is expressed in osteoblast-like cells and is upregulated by 1,25(OH)2 vitamin D3. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
29乯Kawaguchi N., Yamashita T., TsujiK., Wong B., Nabeshima Y., Choi Y. and Noda M. Soluble TRANCE(RANKL, ODF) receptor blocks development of osteoclast-like cells in klotho mutant mice-derived bone marrow cells cultured in the presence of the mutant mice serum. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
30乯Takazawa Y., Tsuji K., Ito Y., Nifuji A. and Noda M. CBFA1 is constitutively expressed in the chondrocytic cell line, TC6, and its expression is upregulated by BMP2. Second Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, California, U.S.A. December 1-6, 1998. The Journal of Bone and Mineral Research 23.
31) Tsuji K., Kraut N., Groudine M., and Noda M. A Transcription modulator, I-MFA (Inhibitor of Myod Family A), is expressed in osteoblast-like cells and is upregulated by 1,25-dihydroxyvitamin D3. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
32) Takazawa Y., Tsuji K., Nifuji A., Kurosawa H., Ito Y., and Noda M. CBFA1 is constitutively expressed in the chondrocytic cell line, TC6, and its expression is upregulated by BMP2. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
33) Sekiya I., Tsuji K., Nifuji A., Wheatly S.W., Shinomiya K., Koopman P., and Noda M. Retinoic acid reduces cartilage phenotype expression through suppression of Sox9 expression. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
34) Yoshitake H., Rittling S., Denhardt D.T., and Noda M. Osteopontin knock-out mice do not lose bone after ovariectomy. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
35) Takazawa Y., Rittling S., Furuya K., Yoshitake H., Yamashita T., Denhardt D., and Noda M. Interleukin-1-induced bone loss is blocked in osteopontin-knock-out mice. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
36) Sekiya I., Rittling S., Yoshitake H., Yamashita T., Denhardt D., and Noda M. Osteopontin knock-out mice are resistant to disuse osteoporosis. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
37) Yoshitake H., Rittling S., Tsuji K., Yamashita T., Denhardt D., and Noda M. Osteopontin knock-out mice are resistant to bone resorption after bone formation induced by bone marrow ablation. 45th Annual Meeting of Orthopaedic Research Society, Anaheim, California, U. S. A. February 1-4, 1999.
38) Asou Y., Rittling S., Yoshitake H., Denhardt D., and Noda M. Osteopntin-Dificient Bone Is Defective in Angiogenesis, Osteoclast-Recruitment and Ectopic Resorption. Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
39) Nemoto H., Rittling S., Yoshitake S., Nifuji A., Denhardt D., and Noda M. Osteopontin (OPN) Promotes Tumor Cell Metastasis to Bone and Soft Tissues.Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
40) Ishijima M., Rittling S., Yoshitake H., Yamashita T., Kurosawa H., Nifuji A., Denhardt D., and Noda M. Osteopontin-Deficiency Protects Bone against Osteopenia Induced by the Absence of Mechanical Stress.Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
41) Tsuji K., Ito Y., and M. Noda. Basic FGF Down-regulates Cbfa1 Expression in Osteoblast-like Cells. Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
42) Sekiya I., Tsuji K., Koopman P., Ito Y., Yamada Y., Shinomiya K., Nifuji A., and Noda M. Dexamethasone Promotes Chondrocyte ADifferentiation thorough Enhancement of Sox9 Expression.Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
43) Yamashita T., Kawaguchi N., Nabeshima Y. and Noda M. Site-Specific Reduction of Osteoclast Number and Size in Klotho Mutant Mice That Exhibit a Syndrome Resembling Precocious Aging of Human. Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
44) Kawaguchi N., Ono T., Kozuka D., Mochii M. and Noda M. A Novel Type of Double Mutation in Mitf, a bHLH-LZ-Type Transcription Factor in Silver Quail , Results in Osteopetrosis. Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
45)Nifuji A., Miura N., Kellermann O. and Noda M. BMP Regulation of Forkhead/Winged Helix Transcription Factor, MFH1, in Murine Mesodermal Cell Line C1 and in Skeletal development. Twenty-First Annual Meeting of the American Society for Bone and Mineral Research, St.Louis, Missouri, U.S.A. September 30-October 4, 1999.
46)Ishijima M., Rittling, S. R., Yoshitake H., Yamashita T.,Kurosawa H., Nifuji A., Denhardt D. T., and Noda M. Osteopontin is required for bone loss induced by the absence of mechanical stress. 46th Annual Meeting of Orthopaedic Research Society , Orland ,Florida, U.S.A. March 12-15, 2000.
47)Asou Y., Rittling S.R., Yoshitake H., Shinomiya K., Nifuji A., Denhardt D.T., and Noda M. Osteopontin in bone facilitates angiogenesis that is required for bone resorption. 46th Annual Meeting of Orthopaedic Research Society , Orland ,Florida, U.S.A. March 12-15, 2000.
48) Asou Y., Yamashita T., Nifuji A., Shinomiya K., Nabeshima Y., and Noda M. Aberrant maturation of growth plate chondrobytes in klotho mutant mice.46th Annual Meeting of Orthopaedic Research Society , Orland ,Florida, U.S.A. March 12-15, 2000.
49)Yamashita T., Higashio K., Nabeshima Y. and Noda M. Double Mutant Mice that Lack Both Klotho and OCIF/OPG Genes Reversed Osteopetrotic Klotho Phenotype in Cancellouse Bone to Normal. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
50) Furuya K., Nakamoto T., Shen Z., Rittling S., Nifuji A., Tsuji K., Denhardt D.T., Hirai H., and Noda M. Cas-Interacting Zinc Finger Protein (CAZ), A Shuttling Molecule Signaling from Attachment Complex to Nuclei, Regulates Type I Collagen Gene Expression and Proliferation in Osteoblast-like Cells. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
51) Usui M., Yoshida Y., Yamashita T., Nifuji A., Ishikawa I., Yamamoto T. and Noda M. Deficiency of a Gene Encoding Antiproliferative Protein, Tob, Enhances BMP-Induced Bone Formaiton in Knock-out Mice: Identification of a Novel Type Inhibitor of BMP. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
52) Takamoto M., Tsuji K., Yamashita T., Nifuji A., Komori T and Noda M. Hedgehog Signaling Activates Cbfa1 Gene Expression in Chondrocytes thorough a Responsive Region in the Promoter Identified by Deletion Analysis. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
114. Ishijima M., Rittling S. R., Tsuji K., Yamashita T., Nifuji A., Kurosawa H., Denhardt D. T. and Noda M. Disruption of Mechano-sensing Signals in Osteoblasts and Osteoclasts in Tail-suspended Osteopontin-knock-out Mice in vivo and their Cells Exposed to Flow Stimuli. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
53)Asou Y., Amizuka N., Yamashita T., Nabeshima Y., Ozawa H. and Noda M. Reduction in the Number of Chondrocyte Columns and in the Height of Prehypertrophic/ Hypertrophic Zone in Growth Plate Temporarily Associate with Bone Phenotypes in Klotho Mutant Mice. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
54)Ihara H., Rittling S.R., Furuya K., Yamashita T., Tsuji K. Hrsuka K. A., Enomoto S., Nifuji A., Denhardt D. T and Noda M. Osteopontin-Deficiency Suppresses PTH/RANKL-Induced Bone Resorption in Organ Cultures. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
55)Tsuji K., Ito Y. and Noda M. Identification of A Novel C-terminal Exon of Pebp2兛B/Cbfa2/AML1 (Runx1). Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.
56) Kawaguchi N. and Noda M. Mitf is Expressed in Osteoclast Progenitors In Vitro. Twenty-Second Annual Meeting of the American Society for Bone and Mineral Research, Toronto, Ontario, Canada. September 22-26, 2000.